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Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer.
Vilimas, Tomas; Wang, Amy Q; Patnaik, Samarjit; Hughes, Emma A; Singleton, Marc D; Knotts, Zachary; Li, Dandan; Frankowski, Kevin; Schlomer, Jerome J; Guerin, Theresa M; Springer, Stephanie; Drennan, Catherine; Dextras, Christopher; Wang, Chen; Gilbert, Debra; Southall, Noel; Ferrer, Marc; Huang, Sui; Kozlov, Serguei; Marugan, Juan; Xu, Xin; Rudloff, Udo.
Afiliación
  • Vilimas T; Molecular Characterization Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, 21702, USA.
  • Wang AQ; Therapeutics for Rare and Neglected Diseases (TRND) Program, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD, 20850, USA.
  • Patnaik S; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD, 20850, USA.
  • Hughes EA; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, 94158, USA.
  • Singleton MD; Biophysics Graduate Group, University of California Berkeley, Berkeley, CA, 94720, USA.
  • Knotts Z; Rare Tumor Initiative (RTI), Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Hatfield Center, 10 Center Drive, 9000 Rockville Pike, Bethesda, MD, 20892, USA.
  • Li D; Rare Tumor Initiative (RTI), Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Hatfield Center, 10 Center Drive, 9000 Rockville Pike, Bethesda, MD, 20892, USA.
  • Frankowski K; Department of Medicinal Chemistry and Specialized Chemistry Center, University of Kansas, Lawrence, KS, USA.
  • Schlomer JJ; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, 21702, USA.
  • Guerin TM; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, 21702, USA.
  • Springer S; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, 21702, USA.
  • Drennan C; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, 21702, USA.
  • Dextras C; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD, 20850, USA.
  • Wang C; Department of Cell and Molecular Biology, Northwestern University, Chicago, IL, 60611, USA.
  • Gilbert D; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, 21702, USA.
  • Southall N; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD, 20850, USA.
  • Ferrer M; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD, 20850, USA.
  • Huang S; Department of Cell and Molecular Biology, Northwestern University, Chicago, IL, 60611, USA.
  • Kozlov S; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, 21702, USA.
  • Marugan J; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD, 20850, USA. maruganj@mail.nih.gov.
  • Xu X; NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bldg B, Rockville, MD, 20850, USA. maruganj@mail.nih.gov.
  • Rudloff U; Therapeutics for Rare and Neglected Diseases (TRND) Program, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD, 20850, USA. xin.xu3@nih.gov.
Cancer Chemother Pharmacol ; 82(6): 1067-1080, 2018 12.
Article en En | MEDLINE | ID: mdl-30306263
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Pirimidinas / Pirroles / Orgánulos / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cancer Chemother Pharmacol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Pirimidinas / Pirroles / Orgánulos / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cancer Chemother Pharmacol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos