Tumor-driven like macrophages induced by conditioned media from pancreatic ductal adenocarcinoma promote tumor metastasis via secreting IL-8.

Chen, Shao-Jie; Lian, Guo-da; Li, Jia-Jia; Zhang, Qiu-Bo; Zeng, Lin-Juan; Yang, Ke-Ge; Huang, Chu-Mei; Li, Ya-Qing; Chen, Yin-Ting; Huang, Kai-Hong

Chen, Shao-Jie; Lian, Guo-da; Li, Jia-Jia; Zhang, Qiu-Bo; Zeng, Lin-Juan; Yang, Ke-Ge; Huang, Chu-Mei; Li, Ya-Qing; Chen, Yin-Ting; Huang, Kai-Hong.

Afiliación

Chen SJ; Department of Gastroenterology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Lian GD; Department of Gastroenterology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Li JJ; Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Zhang QB; Department of Gastroenterology, Lihuili Hospital of Ningbo Medical Center, Ningbo, China.
Zeng LJ; Department of Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
Yang KG; Department of Gastroenterology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Huang CM; Department of Gastroenterology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Li YQ; Department of Gastroenterology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Chen YT; Department of Gastroenterology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Huang KH; Department of Gastroenterology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Cancer Med ; 7(11): 5679-5690, 2018 11.

Article en En | MEDLINE | ID: mdl-30311406

Asunto(s)

Carcinoma Ductal Pancreático/patología; Interleucina-8/genética; Interleucina-8/metabolismo; Macrófagos/metabolismo; Monocitos/citología; Neoplasias Pancreáticas/patología; Animales; Carcinoma Ductal Pancreático/genética; Carcinoma Ductal Pancreático/metabolismo; Diferenciación Celular/efectos de los fármacos; Línea Celular Tumoral; Movimiento Celular/efectos de los fármacos; Medios de Cultivo Condicionados/farmacología; Transición Epitelial-Mesenquimal; Regulación Neoplásica de la Expresión Génica; Humanos; Macrófagos/patología; Ratones; Monocitos/efectos de los fármacos; Monocitos/metabolismo; Metástasis de la Neoplasia; Trasplante de Neoplasias; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/metabolismo; Factor de Transcripción STAT3/metabolismo; Transducción de Señal; Células THP-1; Microambiente Tumoral; Regulación hacia Arriba; Neoplasias Pancreáticas

Palabras clave

IL-8; epithelial-mesenchymal transition; inflammatory microenvironment; pancreatic ductal adenocarcinoma; tumor-associated macrophages

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Monocitos / Interleucina-8 / Carcinoma Ductal Pancreático / Macrófagos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cancer Med Año: 2018 Tipo del documento: Article País de afiliación: China

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