The M6 cell: A small-field bistratified photosensitive retinal ganglion cell.
J Comp Neurol
; 527(1): 297-311, 2019 01 01.
Article
en En
| MEDLINE
| ID: mdl-30311650
ABSTRACT
We have identified a novel, sixth type of intrinsically photosensitive retinal ganglion cell (ipRGC) in the mouse-the M6 cell. Its spiny, highly branched dendritic arbor is bistratified, with dendrites restricted to the inner and outer margins of the inner plexiform layer, co-stratifying with the processes of other ipRGC types. We show that M6 cells are by far the most abundant ganglion cell type labeled in adult pigmented Cdh3-GFP BAC transgenic mice. A few M5 ipRGCs are also labeled, but no other RGC types were encountered. Several distinct subnuclei in the geniculate complex and the pretectum contain labeled retinofugal axons in the Cdh3-GFP mouse. These are presumably the principle central targets of M6 cells (as well as M5 cells). Projections from M6 cells to the dorsal lateral geniculate nucleus were confirmed by retrograde tracing, suggesting they contribute to pattern vision. M6 cells have low levels of melanopsin expression and relatively weak melanopsin-dependent light responses. They also exhibit strong synaptically driven light responses. Their dendritic fields are the smallest and most abundantly branched of all ipRGCs. They have small receptive fields and strong antagonistic surrounds. Despite deploying dendrites partly in the OFF sublamina, M6 cells appear to be driven exclusively by the ON pathway, suggesting that their OFF arbor, like those of certain other ipRGCs, may receive ectopic input from passing ON bipolar cells axons in the OFF sublayer.
Palabras clave
RRID: AB_11214110; RRID: AB_141359; RRID: AB_141637; RRID: AB_141844; RRID: AB_141930; RRID: AB_142540; RRID: AB_143165; RRID: AB_1608077; RRID: AB_2079751; RRID: AB_221570; RRID: AB_2534105; RRID: AB_2535792; RRID: AB_2536190; RRID: AB_2716806; cadherin; ganglion cell photoreceptors; intrinsically photosensitive; lateral geniculate nucleus; melanopsin; retinal ganglion cells
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Células Ganglionares de la Retina
Límite:
Animals
Idioma:
En
Revista:
J Comp Neurol
Año:
2019
Tipo del documento:
Article