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Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing α7 nAChR activities.
Yang, Xicheng; Shen, Jian; Jiang, Lulu; Li, Wei; Yu, Mingcheng; Pan, Guanxing; Yan, Yurong; Zhang, Chenghan; Jia, Wanwan; Xiao, Li; Yu, Haihua; Chen, Hao; Zheng, Yilin; Yu, Linqian; Xie, Qiong; Zhou, Lu; Shao, Liming.
Afiliación
  • Yang X; School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
  • Shen J; School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China; Market Supervision and Administration, 9 Hongxing Road, Economic and Technological Development Zones, Nantong, Jiangsu, 226000, PR China.
  • Jiang L; School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
  • Li W; School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
  • Yu M; School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
  • Pan G; School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China; School of Basic Medical Sciences, Fudan University, 130 Dongan Road, Shanghai 200032, PR China.
  • Yan Y; School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
  • Zhang C; School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
  • Jia W; School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
  • Xiao L; School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
  • Yu H; School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
  • Chen H; School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
  • Zheng Y; School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
  • Yu L; School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China.
  • Xie Q; School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China. Electronic address: qxie@fudan.edu.cn.
  • Zhou L; School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China. Electronic address: zhoulu@fudan.edu.cn.
  • Shao L; School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Hi-tech Park, Pudong, Shanghai 201203, PR China; State Key Laboratory of Medical Neurobiology, Fudan University, 138 Yixueyuan Road, Shanghai, 200032, PR China. Electronic address: limingshao@fudan.edu.cn.
Eur J Med Chem ; 160: 37-48, 2018 Dec 05.
Article en En | MEDLINE | ID: mdl-30317024
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piperidinas / Proteínas Portadoras / Agonistas Nicotínicos / Descubrimiento de Drogas / Receptor Nicotínico de Acetilcolina alfa 7 Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piperidinas / Proteínas Portadoras / Agonistas Nicotínicos / Descubrimiento de Drogas / Receptor Nicotínico de Acetilcolina alfa 7 Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article