Adenosine as a Marker and Mediator of Cardiovascular Homeostasis: A Translational Perspective.
Cardiovasc Hematol Disord Drug Targets
; 19(2): 109-131, 2019.
Article
en En
| MEDLINE
| ID: mdl-30318008
ABSTRACT
Adenosine, a purine nucleoside, is produced broadly and implicated in the homeostasis of many cells and tissues. It signals predominantly via 4 purinergic adenosine receptors (ADORs) - ADORA1, ADORA2A, ADORA2B and ADOosine signaling, both through design as specific ADOR agonists and antagonists and as offtarget effects of existing anti-platelet medications. Despite this, adenosine has yet to be firmly established as either a therapeutic or a prognostic tool in clinical medicine to date. Herein, we provide a bench-to-bedside review of adenosine biology, highlighting the key considerations for further translational development of this proRA3 in addition to non-ADOR mediated effects. Through these signaling mechanisms, adenosine exerts effects on numerous cell types crucial to maintaining vascular homeostasis, especially following vascular injury. Both in vitro and in vivo models have provided considerable insights into adenosine signaling and identified targets for therapeutic intervention. Numerous pharmacologic agents have been developed that modulate adenmising molecule.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sistema Cardiovascular
/
Adenosina
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Cardiovasc Hematol Disord Drug Targets
Asunto de la revista:
ANGIOLOGIA
/
CARDIOLOGIA
/
HEMATOLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
2019
Tipo del documento:
Article
País de afiliación:
Canadá