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Distributed network interactions and their emergence in developing neocortex.
Smith, Gordon B; Hein, Bettina; Whitney, David E; Fitzpatrick, David; Kaschube, Matthias.
Afiliación
  • Smith GB; Department of Functional Architecture and Development of Cerebral Cortex, Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA.
  • Hein B; Optical and Brain Science Medical Discovery Team, Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
  • Whitney DE; Frankfurt Institute for Advanced Studies, Frankfurt, Germany.
  • Fitzpatrick D; International Max Planck Research School for Neural Circuits, Frankfurt, Germany.
  • Kaschube M; Department of Functional Architecture and Development of Cerebral Cortex, Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA.
Nat Neurosci ; 21(11): 1600-1608, 2018 11.
Article en En | MEDLINE | ID: mdl-30349107
The principles governing the functional organization and development of long-range network interactions in the neocortex remain poorly understood. Using in vivo widefield and two-photon calcium imaging of spontaneous activity patterns in mature ferret visual cortex, we find widespread modular correlation patterns that accurately predict the local structure of visually evoked orientation columns several millimeters away. Longitudinal imaging demonstrates that long-range spontaneous correlations are present early in cortical development before the elaboration of horizontal connections and predict mature network structure. Silencing feedforward drive through retinal or thalamic blockade does not eliminate early long-range correlated activity, suggesting a cortical origin. Circuit models containing only local, but heterogeneous, connections are sufficient to generate long-range correlated activity by confining activity patterns to a low-dimensional subspace via multisynaptic short-range interactions. These results suggest that local connections in early cortical circuits can generate structured long-range network correlations that guide the formation of visually evoked distributed functional networks.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neocórtex / Red Nerviosa Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neocórtex / Red Nerviosa Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos