Synthesis and Evaluation of Antifungal and Antitrypanosomastid Activities of Symmetrical 1,4-Disubstituted-1,2,3-Bistriazoles Obtained by CuAAC Conditions.

Victor, Mauricio M; Farias, Ravir R; da Silva, Danielle L; do Carmo, Paulo H F; de Resende-Stoianoff, Maria A; Viegas, Cláudio; Espuri, Patrícia F; Marques, Marcos J

Victor, Mauricio M; Farias, Ravir R; da Silva, Danielle L; do Carmo, Paulo H F; de Resende-Stoianoff, Maria A; Viegas, Cláudio; Espuri, Patrícia F; Marques, Marcos J.

Afiliación

Victor MM; Department of Organic Chemistry, Chemistry Institute, Federal University of Bahia, Salvador 40170-115, BA, Brazil.
Farias RR; National Institute of Science and Technology for Energy and Environmental, Salvador 40170-115, BA, Brazil.
da Silva DL; Department of Organic Chemistry, Chemistry Institute, Federal University of Bahia, Salvador 40170-115, BA, Brazil.
do Carmo PHF; National Institute of Science and Technology for Energy and Environmental, Salvador 40170-115, BA, Brazil.
de Resende-Stoianoff MA; Department of Microbiology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte 31270- 901, MG, Brazil.
Viegas C; Department of Microbiology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte 31270- 901, MG, Brazil.
Espuri PF; Department of Microbiology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte 31270- 901, MG, Brazil.
Marques MJ; PeQuim - Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas, Alfenas 37130-000, MG, Brazil.

Med Chem ; 15(4): 400-408, 2019.

Article en En | MEDLINE | ID: mdl-30360747

Asunto(s)

Alquinos/química; Azidas/química; Cobre/química; Hongos/efectos de los fármacos; Leishmania/efectos de los fármacos; Triazoles/química; Triazoles/farmacología; Antifúngicos/síntesis química; Antifúngicos/química; Antifúngicos/farmacología; Catálisis; Técnicas de Química Sintética; Tripanocidas/síntesis química; Tripanocidas/química; Tripanocidas/farmacología

Palabras clave

Antifungal activity; CuAAC methodology; Mass spectral analysis; antitrypanosomastid activity; fungi; symmetrical bistriazoles.

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Azidas / Triazoles / Cobre / Alquinos / Hongos / Leishmania Idioma: En Revista: Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Brasil

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