Etiology, clinical course and outcome of infant epilepsy: Experience of a tertiary center in Thailand.
J Clin Neurosci
; 59: 119-123, 2019 Jan.
Article
en En
| MEDLINE
| ID: mdl-30415888
ABSTRACT
PURPOSE:
Explore etiology, clinical course and outcome of infant epilepsy in Bhumibol Adulyadej Hospital.METHOD:
Retrospective and prospective descriptive analysis of infants 1â¯month to 1â¯year diagnosed with epilepsy between January 1, 2012, and April 30, 2018.RESULTS:
Total 57 infants. Average age of seizure onset was 4.7â¯months. Follow-up period averaged 34.2â¯months. Prenatal risk factors were found in 28.1 percent (16/57). Of these, 50 percent (8/16) had seizure in neonatal period. An additional 6 infants without any prenatal risk factor had seizure in the neonatal period, bringing the total newborn with seizure to 24.6 percent (14/57). Family history of seizure was positive in only 15.8 percent (9/57). Neuroimaging was done 68.4 percent (39/57) and electroencephalogram 50.9 percent (29/57). The etiology was mostly structural 38.6 percent (22/57), followed by unknown 35.1 percent (20/57), genetics 14 percent (8/57), infection 10.5 percent (6/57) and metabolic 1.8 percent (1/57). Status epilepticus was found 21.1 percent of the times (12/57). Antiepileptic drugs were discontinued 19.3 percent (11/57). Intractable seizure was found 29.8 percent (17/57) and developmental delay 56.1 percent (32/57). By multivariate logistic regression analysis, status epilepticus and developmental delay predicted intractable seizure, whereas, abnormal neurological examination and abnormal neuroimaging predicted developmental delay. Mortality rate was 3.5 percent.CONCLUSION:
The study shows that early onset of epilepsy in children under a year is similar to that found in children less than 2-3â¯years as found in prior studies. High percentages of intractable seizure and developmental delay were found.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Discapacidades del Desarrollo
/
Epilepsia
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
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Infant
/
Newborn
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Clin Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2019
Tipo del documento:
Article