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Zinc(II)-Dipicolylamine Coordination Nanotheranostics: Toward Synergistic Nanomedicine by Combined Photo/Gene Therapy.
Chu, Chengchao; Ren, En; Zhang, Yunming; Yu, Jingwen; Lin, Huirong; Pang, Xin; Zhang, Yang; Liu, Heng; Qin, Zainen; Cheng, Yi; Wang, Xiaoyong; Li, Wei; Kong, Xiangjian; Chen, Xiaoyuan; Liu, Gang.
Afiliación
  • Chu C; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen, Xiamen University, Xiamen, 361102, China.
  • Ren E; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen, Xiamen University, Xiamen, 361102, China.
  • Zhang Y; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen, Xiamen University, Xiamen, 361102, China.
  • Yu J; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Medical College of Xiamen University, Xiamen, 361102, China.
  • Lin H; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen, Xiamen University, Xiamen, 361102, China.
  • Pang X; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen, Xiamen University, Xiamen, 361102, China.
  • Zhang Y; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen, Xiamen University, Xiamen, 361102, China.
  • Liu H; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen, Xiamen University, Xiamen, 361102, China.
  • Qin Z; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen, Xiamen University, Xiamen, 361102, China.
  • Cheng Y; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen, Xiamen University, Xiamen, 361102, China.
  • Wang X; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen, Xiamen University, Xiamen, 361102, China.
  • Li W; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Medical College of Xiamen University, Xiamen, 361102, China.
  • Kong X; State Key Laboratory of Physical Chemistry of Solid Surfaces & The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.
  • Chen X; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.
  • Liu G; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen, Xiamen University, Xiamen, 361102, China.
Angew Chem Int Ed Engl ; 58(1): 269-272, 2019 01 02.
Article en En | MEDLINE | ID: mdl-30421488
ABSTRACT
We report the rational design of coordination-driven self-assembly metal-organic nanostructures for multifunctional nanotheranostics. Zinc(II) coordination-based nano-formulations capable of loading indocyanine green (ICG) and therapeutic genes were prepared to achieve a fluorescence/photoacoustic imaging-guided combination photo/gene therapy strategy. We showed the enhanced theranostic capability of zinc(II)-dipicolylamine-assisted assembly of ICG, as well as simultaneous targeted gene delivery in an experimental mouse model of cancer. Such a co-assembly strategy provides a facile way to achieve combined therapeutic functions for personalized nanomedicine.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fototerapia / Zinc / Terapia Genética / Nanomedicina Límite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Año: 2019 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fototerapia / Zinc / Terapia Genética / Nanomedicina Límite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Año: 2019 Tipo del documento: Article País de afiliación: China