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Molecular evolutionary and antigenic characteristics of newly isolated H9N2 avian influenza viruses in Guangdong province, China.
Zhang, Jipei; Wu, Huiji; Zhang, Yishan; Cao, Mengrui; Brisse, Morgan; Zhu, Wanjun; Li, Rongxu; Liu, Minfang; Cai, Mingsheng; Chen, Jianhong; Chen, Jidang.
Afiliación
  • Zhang J; School of Life Science and Engineering, Foshan University, Foshan, 528000, Guangdong, People's Republic of China.
  • Wu H; School of Life Science and Engineering, Foshan University, Foshan, 528000, Guangdong, People's Republic of China.
  • Zhang Y; School of Life Science and Engineering, Foshan University, Foshan, 528000, Guangdong, People's Republic of China.
  • Cao M; School of Life Science and Engineering, Foshan University, Foshan, 528000, Guangdong, People's Republic of China.
  • Brisse M; College of Veterinary Medicine, University of Minnesota, Twin Cites Campus, Saint Paul, MN, 55108, USA.
  • Zhu W; School of Life Science and Engineering, Foshan University, Foshan, 528000, Guangdong, People's Republic of China.
  • Li R; College of Veterinary Medicine, University of Minnesota, Twin Cites Campus, Saint Paul, MN, 55108, USA.
  • Liu M; School of Life Science and Engineering, Foshan University, Foshan, 528000, Guangdong, People's Republic of China.
  • Cai M; School of Life Science and Engineering, Foshan University, Foshan, 528000, Guangdong, People's Republic of China.
  • Chen J; Department of Pathogenic Biology and Immunology, Sino-French Hoffmann Institute, School of Basic Medical Science, Guangzhou Medical University, Xinzao Town, Panyu, Guangzhou, 511436, Guangdong, People's Republic of China.
  • Chen J; School of Life Science and Engineering, Foshan University, Foshan, 528000, Guangdong, People's Republic of China. jianhongchen2012@126.com.
Arch Virol ; 164(2): 607-612, 2019 Feb.
Article en En | MEDLINE | ID: mdl-30474753
ABSTRACT
Four new H9N2 avian influenza viruses (AIVs) were isolated from domestic birds in Guangdong between December 2015 and April 2016. Nucleotide sequence comparisons indicated that most of the internal genes of these four strains were highly similar to those of human H7N9 viruses. Amino acid substitutions and deletions found in the HA and NA proteins indicated that all four of these new isolates may have an enhanced ability to infect humans and other mammals. A cross-hemagglutinin-inhibition assay, conducted with two vaccine strains that are broadly used in China, suggested that antisera against vaccine candidates could not provide complete inhibition of the new isolates.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades de las Aves de Corral / Evolución Molecular / Subtipo H9N2 del Virus de la Influenza A / Gripe Aviar / Antígenos Virales Límite: Animals / Humans País/Región como asunto: Asia Idioma: En Revista: Arch Virol Año: 2019 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades de las Aves de Corral / Evolución Molecular / Subtipo H9N2 del Virus de la Influenza A / Gripe Aviar / Antígenos Virales Límite: Animals / Humans País/Región como asunto: Asia Idioma: En Revista: Arch Virol Año: 2019 Tipo del documento: Article