Mycoplasma promotes malignant transformation in vivo, and its DnaK, a bacterial chaperone protein, has broad oncogenic properties.

Zella, Davide; Curreli, Sabrina; Benedetti, Francesca; Krishnan, Selvi; Cocchi, Fiorenza; Latinovic, Olga S; Denaro, Frank; Romerio, Fabio; Djavani, Muhammad; Charurat, Man E; Bryant, Joseph L; Tettelin, Hervé; Gallo, Robert C

Zella, Davide; Curreli, Sabrina; Benedetti, Francesca; Krishnan, Selvi; Cocchi, Fiorenza; Latinovic, Olga S; Denaro, Frank; Romerio, Fabio; Djavani, Muhammad; Charurat, Man E; Bryant, Joseph L; Tettelin, Hervé; Gallo, Robert C.

Afiliación

Zella D; Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, MD 21201; dzella@ihv.umaryland.edu rgallo@ihv.umaryland.edu.
Curreli S; Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD 21201.
Benedetti F; Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, MD 21201.
Krishnan S; Department of Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201.
Cocchi F; Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, MD 21201.
Latinovic OS; Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD 21201.
Denaro F; Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, MD 21201.
Romerio F; Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, MD 21201.
Djavani M; Department of Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201.
Charurat ME; Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, MD 21201.
Bryant JL; Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, MD 21201.
Tettelin H; Department of Biology, Morgan State University, Baltimore, MD 21251.
Gallo RC; Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, MD 21201.

Proc Natl Acad Sci U S A ; 115(51): E12005-E12014, 2018 12 18.

Article en En | MEDLINE | ID: mdl-30509983

Asunto(s)

Adenosina Trifosfatasas/genética; Proteínas Bacterianas/genética; Carcinogénesis/genética; Transformación Celular Neoplásica/genética; Chaperonas Moleculares/genética; Mycoplasma/genética; Adenosina Trifosfatasas/clasificación; Animales; Antineoplásicos/uso terapéutico; Proteínas Bacterianas/clasificación; Transformación Celular Neoplásica/efectos de los fármacos; Transformación Celular Neoplásica/metabolismo; Reparación del ADN; ADN Bacteriano/genética; Proteína Quinasa Activada por ADN/metabolismo; Modelos Animales de Enfermedad; Genes Bacterianos/genética; Células HCT116; Proteínas HSP70 de Choque Térmico/metabolismo; Humanos; Linfoma/genética; Linfoma/microbiología; Linfoma/patología; Ratones; Ratones SCID; Chaperonas Moleculares/clasificación; Mycoplasma/patogenicidad; Infecciones por Mycoplasma/microbiología; Mycoplasma fermentans/genética; Mycoplasma fermentans/patogenicidad; Oncogenes; Filogenia; Poli(ADP-Ribosa) Polimerasa-1/metabolismo; Análisis de Secuencia; Análisis de Secuencia de Proteína; Proteína p53 Supresora de Tumor/metabolismo; Ubiquitina Tiolesterasa/metabolismo

Palabras clave

DNA repair; DnaK; cancer; mycoplasma; p53

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Transformación Celular Neoplásica / Adenosina Trifosfatasas / Chaperonas Moleculares / Carcinogénesis / Mycoplasma Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2018 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google