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Liver-Specific Delivery of Sleeping Beauty Transposon System by Hydrodynamic Injection for Cancer Gene Validation.
Chiu, Amy P; Keng, Vincent W.
Afiliación
  • Chiu AP; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.
  • Keng VW; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China. vincent.keng@polyu.edu.hk.
Methods Mol Biol ; 1907: 185-196, 2019.
Article en En | MEDLINE | ID: mdl-30543001
ABSTRACT
Understanding the complex genetic background of cancers is key in developing effective targeted therapies. The Sleeping Beauty (SB) transposon system is a powerful and unbiased genetic editing tool that can be used for rapid screening of candidate liver cancer driver genes. Manipulating their expression level using a reverse genetic mouse model involving hydrodynamic tail-vein injection delivery can rapidly elucidate the role of these candidate genes in liver cancer tumorigenesis.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Plásmidos / Elementos Transponibles de ADN / Transposasas / Hidrodinámica / Hígado / Neoplasias Hepáticas / Proteínas de Neoplasias Límite: Animals / Humans Idioma: En Revista: Methods Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2019 Tipo del documento: Article País de afiliación: China
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Plásmidos / Elementos Transponibles de ADN / Transposasas / Hidrodinámica / Hígado / Neoplasias Hepáticas / Proteínas de Neoplasias Límite: Animals / Humans Idioma: En Revista: Methods Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2019 Tipo del documento: Article País de afiliación: China