Deception through Mimicry: A Cellular Antiviral Strategy.

Wu, Nicholas C; Ward, Andrew B

Wu, Nicholas C; Ward, Andrew B.

Afiliación

Wu NC; Department of Integrative Structural and Computational Biology, the Scripps Research Institute, La Jolla, CA 92037, USA.
Ward AB; Department of Integrative Structural and Computational Biology, the Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: andrew@scripps.edu.

Cell ; 175(7): 1728-1729, 2018 12 13.

Article en En | MEDLINE | ID: mdl-30550784

ABSTRACT

ABSTRACT

Viruses use mimicry to hijack cellular machinery, but can human cells use mimicry as an antiviral approach? Batra et al. identify a novel antiviral restriction factor, RBBP6, by characterizing the cellular interactome of Ebola virus. RBBP6 targets the Ebola virus transcription factor VP30 by mimicking the binding of Ebola virus nucleoprotein.

Asunto(s)

Antivirales; Ebolavirus/genética; Fiebre Hemorrágica Ebola; Proteínas Portadoras; Proteínas de Unión al ADN; Decepción; Humanos; Mapeo de Interacción de Proteínas; ARN Viral; Transcripción Genética; Ubiquitina-Proteína Ligasas; Proteínas Virales; Replicación Viral

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antivirales / Fiebre Hemorrágica Ebola / Ebolavirus Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cell Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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