Prolonged antibiotic administration for surgical site infection in pediatric laryngotracheal surgery.
Laryngoscope
; 129(11): 2634-2639, 2019 Nov.
Article
en En
| MEDLINE
| ID: mdl-30589074
ABSTRACT
OBJECTIVES/HYPOTHESIS:
Incidence of surgical site infection (SSI) after laryngotracheal (LT) surgery is relatively high, especially in children. STUDYDESIGN:
Retrospective and prospective cohort study.METHODS:
Clinical records of children who underwent open LT surgery at the Istituto Giannina Gaslini Children's Hospital from January 2008 to August 2017 were reviewed for development of SSI. Standard antibiotic prophylaxis was administered until February 2015. In March 2015, an antibiotic treatment tailored on pathogens isolated from surveillance cultures and prolonged until extubation was introduced. Incidence and risk factors for SSI before and after the new protocol implementation were analyzed by means of univariate and multivariable analyses.RESULTS:
A total of 57 procedures were analyzed. SSI incidence was 36% in patients receiving standard prophylaxis and 4% in those treated with the new strategy (P = .004), with an absolute benefit increase of 32% (95% confidence interval 11%-52%), in absence of any difference in clinical conditions between the two groups.CONCLUSIONS:
The new management protocol had a highly favorable impact on the development of an SSI. LEVEL OF EVIDENCE 2b Laryngoscope, 1292634-2639, 2019.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Infección de la Herida Quirúrgica
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Traqueotomía
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Profilaxis Antibiótica
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Laringoscopía
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Antibacterianos
Tipo de estudio:
Etiology_studies
/
Evaluation_studies
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Guideline
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
Laryngoscope
Asunto de la revista:
OTORRINOLARINGOLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Italia