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Single Nucleotide Polymorphisms of PTPN22 Gene in Iranian Patients with Ulcerative Colitis.
Sadr, Maryam; Moazzami, Bobak; Soleimanifar, Narjes; Elhamian, Nazanin; Rezaei, Arezoo; Ebrahimi Daryani, Nasser; Rezaei, Nima.
Afiliación
  • Sadr M; a Molecular Immunology Research Center, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
  • Moazzami B; b Research Center for Immunodeficiencies, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
  • Soleimanifar N; a Molecular Immunology Research Center, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
  • Elhamian N; b Research Center for Immunodeficiencies, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
  • Rezaei A; b Research Center for Immunodeficiencies, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
  • Ebrahimi Daryani N; c Department of Gastroenterology and Hepatology , Tehran University of Medical Sciences , Tehran , Iran.
  • Rezaei N; b Research Center for Immunodeficiencies, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
Fetal Pediatr Pathol ; 38(1): 8-13, 2019 Feb.
Article en En | MEDLINE | ID: mdl-30636557
OBJECTIVES: Protein tyrosine phosphatase non-receptor type 22 gene (PTPN22) single-nucleotide polymorphisms (SNP) have been associated with a number of different autoimmune diseases. This study aimed to investigate the association of five polymorphisms of PTPN22 gene with susceptibility to ulcerative colitis (UC) in Iran. MATERIALS AND METHODS: A total of 67 patients diagnosed with UC (35 female and 32 male all under 18 years) and 93 healthy subjects were selected. The samples were genotyped for the, rs12760457, rs2476601, rs1310182, rs1217414, and rs33996649 in PTPN22 gene using real-time polymerase chain reaction (PCR) allelic discrimination TaqMan genotyping assays. RESULTS: The frequencies of the rs1310182 A and G alleles, and also the AA and GG genotypes were significantly different between the patient and the control groups (p < 0.05). The carriage of G allele of rs1310182 was significantly associated with increased risk of UC (OR (95% CI) = 1.17 (0.70-1.98), p < 0.001). Moreover, the genotype GG of SNP rs1310182 was significantly associated with UC (OR (95% CI) = 2.32 (1.13-4.76), p < 0.01). No association was found between other PTPN22 gene SNPs among UC patients. CONCLUSION: PTPN22 gene polymorphism in rs1310182 could play a crucial role in susceptibility to UC.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Predisposición Genética a la Enfermedad / Proteína Tirosina Fosfatasa no Receptora Tipo 22 Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Fetal Pediatr Pathol Asunto de la revista: PATOLOGIA / PEDIATRIA Año: 2019 Tipo del documento: Article País de afiliación: Irán

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Predisposición Genética a la Enfermedad / Proteína Tirosina Fosfatasa no Receptora Tipo 22 Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Fetal Pediatr Pathol Asunto de la revista: PATOLOGIA / PEDIATRIA Año: 2019 Tipo del documento: Article País de afiliación: Irán