Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability.

Teloni, Federico; Michelena, Jone; Lezaja, Aleksandra; Kilic, Sinan; Ambrosi, Christina; Menon, Shruti; Dobrovolna, Jana; Imhof, Ralph; Janscak, Pavel; Baubec, Tuncay; Altmeyer, Matthias

Teloni, Federico; Michelena, Jone; Lezaja, Aleksandra; Kilic, Sinan; Ambrosi, Christina; Menon, Shruti; Dobrovolna, Jana; Imhof, Ralph; Janscak, Pavel; Baubec, Tuncay; Altmeyer, Matthias.

Afiliación

Teloni F; Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland; Life Science Zurich Graduate School (LSZGS), 8057 Zurich, Switzerland.
Michelena J; Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland.
Lezaja A; Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland; Life Science Zurich Graduate School (LSZGS), 8057 Zurich, Switzerland.
Kilic S; Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland.
Ambrosi C; Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland; Life Science Zurich Graduate School (LSZGS), 8057 Zurich, Switzerland.
Menon S; Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland; Life Science Zurich Graduate School (LSZGS), 8057 Zurich, Switzerland.
Dobrovolna J; Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 143 00 Czech Republic.
Imhof R; Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland.
Janscak P; Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland; Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 143 00 Czech Republic.
Baubec T; Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland.
Altmeyer M; Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland. Electronic address: matthias.altmeyer@uzh.ch.

Mol Cell ; 73(4): 670-683.e12, 2019 02 21.

Article en En | MEDLINE | ID: mdl-30639241

Asunto(s)

Daño del ADN; Replicación del ADN; Inestabilidad Genómica; Neoplasias/genética; División del ARN; Precursores del ARN/genética; ARN Mensajero/genética; ARN Neoplásico/genética; Transporte Activo de Núcleo Celular; Proteínas de Ciclo Celular/genética; Proteínas de Ciclo Celular/metabolismo; ADN de Neoplasias/genética; ADN de Neoplasias/metabolismo; Proteínas de Unión al ADN; Regulación Neoplásica de la Expresión Génica; Células HeLa; Humanos; Neoplasias/metabolismo; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; Ácidos Nucleicos Heterodúplex/genética; Ácidos Nucleicos Heterodúplex/metabolismo; Poliadenilación; Precursores del ARN/biosíntesis; ARN Mensajero/biosíntesis; ARN Neoplásico/biosíntesis; Proteínas de Unión al ARN

Palabras clave

ATR; R-loops; RNA:DNA hybrids; checkpoint activation; cleavage; gene gating; origin firing; polyadenylation; pre-mRNA processing; replication catastrophe; replication stress

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Daño del ADN / ARN Mensajero / ARN Neoplásico / Precursores del ARN / Inestabilidad Genómica / Replicación del ADN / División del ARN / Neoplasias Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2019 Tipo del documento: Article País de afiliación: Suiza

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