The influence of maternal obesity on macrophage subsets in the human decidua.
Cell Immunol
; 336: 75-82, 2019 02.
Article
en En
| MEDLINE
| ID: mdl-30665661
ABSTRACT
Obesity is seen as a low grade inflammatory state, and is associated with adverse pregnancy outcomes. Disturbed macrophage characteristics might be essential in obesity associated pregnancy pathology via effects on the regulation of angiogenesis and placental development. This study aims to address the effects of maternal obesity on macrophage subsets in the decidua of women with term uncomplicated pregnancies. Macrophages were isolated from the decidua basalis and decidua parietalis of women with pre-gravid BMIâ¯<â¯25 (control) and BMIâ¯>â¯30 (obese). Macrophages were characterized and quantified using multi-color flow cytometry. Placentas of 10 obese and 10 control women after an uncomplicated term pregnancy were included. The decidua parietalis, but not decidua basalis, showed significantly lower levels of M1-type (HLA-DR+, CD163-) macrophages (pâ¯<â¯0.05) in obese women (4,3% of total macrophages) compared to control women (5,3% of total macrophages). The lower levels of M1 macrophages, considered to be pro-inflammatory, might indicate a mechanism to compensate for the pro-inflammatory environment in obese women to ensure healthy pregnancy outcomes.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Decidua
/
Obesidad Materna
/
Macrófagos
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Cell Immunol
Año:
2019
Tipo del documento:
Article