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Contribution of immunoglobulin lambda light chain gene rearrangement analysis in the diagnosis of B-cell neoplasms.
Paterson, Anna L; El-Daly, Hesham; Raso-Barnett, Livia; Du, Ming-Qing; Giger, Olivier; Soilleux, Elizabeth; Roberts, Thomas; Huang, Yuanxue; Bibawi, Hani; Matharu, Baljinder; Bench, Anthony; Scott, Mike A; Liu, Hongxiang.
Afiliación
  • Paterson AL; Department of Pathology, Addenbrooke's Hospital, Cambridge University NHS Foundation Trust, Cambridge, UK.
  • El-Daly H; Haematopathology and Oncology Diagnostics Service, Addenbrooke's Hospital, Cambridge University NHS Foundation Trust, Cambridge, UK.
  • Raso-Barnett L; Clinical Pathology Department, University of Cairo, Cairo, Egypt.
  • Du MQ; Haematopathology and Oncology Diagnostics Service, Addenbrooke's Hospital, Cambridge University NHS Foundation Trust, Cambridge, UK.
  • Giger O; Department of Pathology, University of Cambridge, Cambridge, UK.
  • Soilleux E; Department of Pathology, University of Cambridge, Cambridge, UK.
  • Roberts T; Department of Pathology, University of Cambridge, Cambridge, UK.
  • Huang Y; Haematopathology and Oncology Diagnostics Service, Addenbrooke's Hospital, Cambridge University NHS Foundation Trust, Cambridge, UK.
  • Bibawi H; Haematopathology and Oncology Diagnostics Service, Addenbrooke's Hospital, Cambridge University NHS Foundation Trust, Cambridge, UK.
  • Matharu B; Haematopathology and Oncology Diagnostics Service, Addenbrooke's Hospital, Cambridge University NHS Foundation Trust, Cambridge, UK.
  • Bench A; Haematopathology and Oncology Diagnostics Service, Addenbrooke's Hospital, Cambridge University NHS Foundation Trust, Cambridge, UK.
  • Scott MA; Haematopathology and Oncology Diagnostics Service, Addenbrooke's Hospital, Cambridge University NHS Foundation Trust, Cambridge, UK.
  • Liu H; Haematopathology and Oncology Diagnostics Service, Addenbrooke's Hospital, Cambridge University NHS Foundation Trust, Cambridge, UK.
Br J Haematol ; 185(2): 261-265, 2019 04.
Article en En | MEDLINE | ID: mdl-30681735
ABSTRACT
Identification of clonal IGH, IGK and IGL gene rearrangements offers diagnostic adjunct in suspected B-cell neoplasms. However, many centres omit IGL analysis as its value is uncertain. A review of 567 cases with IGH, IGK and IGL rearrangement assessed using BIOMED-2 assays showed clonal immunoglobulin gene rearrangement in 54% of cases, of which 24% had a clonal IGL rearrangement. In two cases, the clonal rearrangement was detected exclusively by IGL analysis. This finding demonstrates the added value of IGL analysis for clonality assessment, especially in suspected B-cell neoplasms in which a clonal IGH and/or IGK rearrangement is not detected or is equivocal.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Reordenamiento Génico de Cadena Ligera de Linfocito B / Linfoma de Células B / Cadenas lambda de Inmunoglobulina / Genes de las Cadenas Ligeras de las Inmunoglobulinas Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Aged / Female / Humans Idioma: En Revista: Br J Haematol Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Reordenamiento Génico de Cadena Ligera de Linfocito B / Linfoma de Células B / Cadenas lambda de Inmunoglobulina / Genes de las Cadenas Ligeras de las Inmunoglobulinas Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Aged / Female / Humans Idioma: En Revista: Br J Haematol Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido