Glucose 6-phosphate dehydrogenase 6-phosphogluconolactonase: characterization of the Plasmodium vivax enzyme and inhibitor studies.

Haeussler, Kristina; Berneburg, Isabell; Jortzik, Esther; Hahn, Julia; Rahbari, Mahsa; Schulz, Norma; Preuss, Janina; Zapol'skii, Viktor A; Bode, Lars; Pinkerton, Anthony B; Kaufmann, Dieter E; Rahlfs, Stefan; Becker, Katja

Haeussler, Kristina; Berneburg, Isabell; Jortzik, Esther; Hahn, Julia; Rahbari, Mahsa; Schulz, Norma; Preuss, Janina; Zapol'skii, Viktor A; Bode, Lars; Pinkerton, Anthony B; Kaufmann, Dieter E; Rahlfs, Stefan; Becker, Katja.

Afiliación

Haeussler K; Biochemistry and Molecular Biology, Interdisciplinary Research Center, Justus Liebig University, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany.
Berneburg I; Biochemistry and Molecular Biology, Interdisciplinary Research Center, Justus Liebig University, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany.
Jortzik E; Biochemistry and Molecular Biology, Interdisciplinary Research Center, Justus Liebig University, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany.
Hahn J; Biochemistry and Molecular Biology, Interdisciplinary Research Center, Justus Liebig University, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany.
Rahbari M; Biochemistry and Molecular Biology, Interdisciplinary Research Center, Justus Liebig University, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany.
Schulz N; Biochemistry and Molecular Biology, Interdisciplinary Research Center, Justus Liebig University, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany.
Preuss J; Biochemistry and Molecular Biology, Interdisciplinary Research Center, Justus Liebig University, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany.
Zapol'skii VA; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Bode L; Department of Pediatrics, University of California San Diego, San Diego, CA, 92093, USA.
Pinkerton AB; Institute of Organic Chemistry, Clausthal University of Technology, 38678, Clausthal-Zellerfeld, Germany.
Kaufmann DE; Department of Pediatrics, University of California San Diego, San Diego, CA, 92093, USA.
Rahlfs S; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Becker K; Institute of Organic Chemistry, Clausthal University of Technology, 38678, Clausthal-Zellerfeld, Germany.

Malar J ; 18(1): 22, 2019 Jan 25.

Article en En | MEDLINE | ID: mdl-30683097

Asunto(s)

Hidrolasas de Éster Carboxílico/genética; Glucosafosfato Deshidrogenasa/genética; Malaria Vivax/genética; Complejos Multienzimáticos/genética; Proteínas Protozoarias/genética; Hidrolasas de Éster Carboxílico/metabolismo; Clonación Molecular; Citosol/metabolismo; Escherichia coli/metabolismo; Glucosafosfato Deshidrogenasa/antagonistas & inhibidores; Glucosafosfato Deshidrogenasa/metabolismo; Cinética; Malaria Vivax/enzimología; Malaria Vivax/metabolismo; Complejos Multienzimáticos/metabolismo; Oxidación-Reducción; Proteínas Protozoarias/metabolismo; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo

Palabras clave

Drug target; Glucose 6-phosphate dehydrogenase; Inhibitors; Malaria; Plasmodium falciparum; Plasmodium vivax; Post-translational modification; Redox balance; SNP

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Hidrolasas de Éster Carboxílico / Proteínas Protozoarias / Malaria Vivax / Glucosafosfato Deshidrogenasa / Complejos Multienzimáticos Idioma: En Revista: Malar J Asunto de la revista: MEDICINA TROPICAL Año: 2019 Tipo del documento: Article País de afiliación: Alemania

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