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Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase.
König, Stefanie; Pace, Simona; Pein, Helmut; Heinekamp, Thorsten; Kramer, Jan; Romp, Erik; Straßburger, Maria; Troisi, Fabiana; Proschak, Anna; Dworschak, Jan; Scherlach, Kirstin; Rossi, Antonietta; Sautebin, Lidia; Haeggström, Jesper Z; Hertweck, Christian; Brakhage, Axel A; Gerstmeier, Jana; Proschak, Ewgenij; Werz, Oliver.
Afiliación
  • König S; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany.
  • Pace S; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany.
  • Pein H; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany.
  • Heinekamp T; Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute (HKI), 07745 Jena, Germany.
  • Kramer J; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany.
  • Romp E; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany.
  • Straßburger M; Transfer Group Antiinfectives, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute (HKI), 07745 Jena, Germany.
  • Troisi F; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany.
  • Proschak A; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany.
  • Dworschak J; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute (HKI), 07745 Jena, Germany.
  • Scherlach K; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute (HKI), 07745 Jena, Germany.
  • Rossi A; Department of Pharmacy, School of Medicine, University of Naples Federico II, 80131 Naples, Italy.
  • Sautebin L; Department of Pharmacy, School of Medicine, University of Naples Federico II, 80131 Naples, Italy.
  • Haeggström JZ; Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.
  • Hertweck C; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute (HKI), 07745 Jena, Germany; Friedrich-Schiller-University Jena, 07743 Jena, Germany.
  • Brakhage AA; Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute (HKI), 07745 Jena, Germany; Friedrich-Schiller-University Jena, 07743 Jena, Germany.
  • Gerstmeier J; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany.
  • Proschak E; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany.
  • Werz O; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, 07743 Jena, Germany. Electronic address: oliver.werz@uni-jena.de.
Cell Chem Biol ; 26(4): 524-534.e5, 2019 04 18.
Article en En | MEDLINE | ID: mdl-30745237
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Aspergilosis / Aspergillus fumigatus / Leucotrieno B4 / Epóxido Hidrolasas / Gliotoxina Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Cell Chem Biol Año: 2019 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Aspergilosis / Aspergillus fumigatus / Leucotrieno B4 / Epóxido Hidrolasas / Gliotoxina Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Cell Chem Biol Año: 2019 Tipo del documento: Article País de afiliación: Alemania