Synthesis of Functionalized Ketones from Acid Chlorides and Organolithiums by Extremely Fast Micromixing.

Nagaki, Aiichiro; Sasatsuki, Kengo; Ishiuchi, Satoshi; Miuchi, Nobuyuki; Takumi, Masahiro; Yoshida, Jun-Ichi

Nagaki, Aiichiro; Sasatsuki, Kengo; Ishiuchi, Satoshi; Miuchi, Nobuyuki; Takumi, Masahiro; Yoshida, Jun-Ichi.

Afiliación

Nagaki A; Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510, Japan.
Sasatsuki K; Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510, Japan.
Ishiuchi S; Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510, Japan.
Miuchi N; Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510, Japan.
Takumi M; Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510, Japan.
Yoshida JI; National Institute of Technology, Suzuka College, Emeritus Professor, Kyoto University, Shiroko-cho, Suzuka, Mie, 510-0294, Japan.

Chemistry ; 25(19): 4946-4950, 2019 Apr 01.

Article en En | MEDLINE | ID: mdl-30775815

ABSTRACT

ABSTRACT

Synthesis of ketones containing various functional groups from acid chlorides bearing electrophilic functional groups and functionalized organolithiums was achieved using a flow microreactor system. Extremely fast mixing is important for high chemoselectivity.

Palabras clave

chemoselectivity; flow microreactor; functionalized ketones; organic synthesis; organolithium

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Japón

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