The clinical value of hematological markers in rheumatoid arthritis patients treated with tocilizumab.
J Clin Lab Anal
; 33(5): e22862, 2019 Jun.
Article
en En
| MEDLINE
| ID: mdl-30779461
ABSTRACT
BACKGROUND:
Emerging evidence indicates that some hematological markers have critical value in evaluating treatment response. This study was performed to determine the clinical value of hemoglobin (Hb), platelet (Plt), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in rheumatoid arthritis (RA) patients treated with tocilizumab (TCZ).METHODS:
Fifty-two RA patients receiving TCZ were recruited and followed for 6 months. The values of abovementioned hematological markers were collected. Clinical disease activity index (CDAI) and disease activity score based on 28 joints (DAS28)-ESR were calculated. Correlation analysis was conducted by calculating Pearson's correlation coefficient. The change in disease activity between groups according to the baseline level of hematological markers was compared by t test.RESULTS:
Significant correlation between change in NLR (â³NLR), change in PLR (â³PLR), and change in CDAI (â³CDAI) was found (â³NLR r = 0.30, P = 0.03; â³PLR r = 0.31, P = 0.03). The change in Plt (â³Plt) was correlated with change in DAS28-ESR (â³DAS28-ESR) (r = 0.36, P = 8.24 × 10-3 ). Greater improvement in CDAI was seen in patients categorized into Plt high group (t = 2.06, P = 0.04), NLR high group (t = 2.15, P = 0.04), and PLR high group (t = 2.41, P = 0.02) compared with the contrast group.CONCLUSION:
Our study demonstrated that â³Plt, â³NLR, and â³PLR could be used to monitor the clinical response to TCZ. RA patients with high baseline levels of Plt, NLR, and PLR achieved more improvement, indicating these hematological markers might be utilized to guide TCZ treatment.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Artritis Reumatoide
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Biomarcadores
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Anticuerpos Monoclonales Humanizados
Tipo de estudio:
Etiology_studies
/
Observational_studies
Límite:
Adult
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Clin Lab Anal
Asunto de la revista:
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Año:
2019
Tipo del documento:
Article
País de afiliación:
China