Activation of AMPK-dependent autophagy in the nucleus accumbens opposes cocaine-induced behaviors of mice.
Addict Biol
; 25(2): e12736, 2020 03.
Article
en En
| MEDLINE
| ID: mdl-30788886
ABSTRACT
Cocaine is a strong central nervous system stimulant, which can induce drug addiction. Previous studies have reported that cocaine-induced autophagy is involved in neuroinflammation and cell death. However, the role of autophagy in psychomotor sensitivity to cocaine has not been explored. Here, we reported that D1 receptor -CaMKII-AMPK-FoxO3a signaling pathway was involved in acute cocaine application-induced autophagy in the nucleus accumbens (NAc) both in vitro and in vivo. Furthermore, we found that knockdown of the ATG5 gene in the NAc augmented behavioral response to cocaine, and induction of autophagy in the NAc with rapamycin attenuated cocaine-induced behavioral response, which was coincident with the alterations of dendritic spine density in neurons of NAc. These results suggest that cocaine exposure leads to the induction of autophagy, which is a protective mechanism against behavioral response to cocaine of male mice.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Autofagia
/
Conducta Animal
/
Cocaína
/
Trastornos Relacionados con Cocaína
/
Proteínas Quinasas Activadas por AMP
/
Núcleo Accumbens
Límite:
Animals
Idioma:
En
Revista:
Addict Biol
Asunto de la revista:
TRANSTORNOS RELACIONADOS COM SUBSTANCIAS
Año:
2020
Tipo del documento:
Article
País de afiliación:
China