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Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic.
Batiste, Suzanne M; Blackwell, Daniel J; Kim, Kyungsoo; Kryshtal, Dmytro O; Gomez-Hurtado, Nieves; Rebbeck, Robyn T; Cornea, Razvan L; Johnston, Jeffrey N; Knollmann, Bjorn C.
Afiliación
  • Batiste SM; Department of Chemistry, Vanderbilt University, Nashville, TN 37235.
  • Blackwell DJ; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232.
  • Kim K; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232.
  • Kryshtal DO; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232.
  • Gomez-Hurtado N; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232.
  • Rebbeck RT; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455.
  • Cornea RL; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455.
  • Johnston JN; Department of Chemistry, Vanderbilt University, Nashville, TN 37235; jeffrey.n.johnston@vanderbilt.edu bjorn.knollmann@vanderbilt.edu.
  • Knollmann BC; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232; jeffrey.n.johnston@vanderbilt.edu bjorn.knollmann@vanderbilt.edu.
Proc Natl Acad Sci U S A ; 116(11): 4810-4815, 2019 03 12.
Article en En | MEDLINE | ID: mdl-30792355
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Bloqueadores de los Canales de Calcio / Calcio / Canal Liberador de Calcio Receptor de Rianodina / Depsipéptidos / Antiarrítmicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2019 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Bloqueadores de los Canales de Calcio / Calcio / Canal Liberador de Calcio Receptor de Rianodina / Depsipéptidos / Antiarrítmicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2019 Tipo del documento: Article