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Knockout of Wdr1 results in cardiac hypertrophy and impaired cardiac function in adult mouse heart.
Huang, Xia; Li, Ziyi; Hu, Jisheng; Yang, Zihao; Liu, Zhongying; Zhang, Tongcun; Zhang, Chenxi; Yuan, Baiyin.
Afiliación
  • Huang X; Biomedical Research Institute, College of Life Science and Health, Wuhan University of Science and Technology, Wuhan, Hubei Province 430081, PR China.
  • Li Z; Biomedical Research Institute, College of Life Science and Health, Wuhan University of Science and Technology, Wuhan, Hubei Province 430081, PR China.
  • Hu J; Biomedical Research Institute, College of Life Science and Health, Wuhan University of Science and Technology, Wuhan, Hubei Province 430081, PR China.
  • Yang Z; Biomedical Research Institute, College of Life Science and Health, Wuhan University of Science and Technology, Wuhan, Hubei Province 430081, PR China.
  • Liu Z; Biomedical Research Institute, College of Life Science and Health, Wuhan University of Science and Technology, Wuhan, Hubei Province 430081, PR China.
  • Zhang T; Biomedical Research Institute, College of Life Science and Health, Wuhan University of Science and Technology, Wuhan, Hubei Province 430081, PR China. Electronic address: zhangtongcun@wust.edu.cn.
  • Zhang C; Central Laboratory, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu Province 210029, PR China. Electronic address: chenxi4262@126.com.
  • Yuan B; Biomedical Research Institute, College of Life Science and Health, Wuhan University of Science and Technology, Wuhan, Hubei Province 430081, PR China. Electronic address: yuanby@wust.edu.cn.
Gene ; 697: 40-47, 2019 May 20.
Article en En | MEDLINE | ID: mdl-30794912
ABSTRACT
WDR1 is a major cofactor of the actin depolymerizing factor (ADF)/cofilin, accelerating ADF/cofilin-mediated actin disassembly. We had previously showed that WDR1-mediated actin dynamics is required for postnatal myocardial growth and adult myocardial maintenance in mice, in which the detailed phenotypes of adult cardiomyocyte-specific Wdr1 deletion mice had not been analyzed. In this study, we systematically analyzed the role of Wdr1 in adult mouse heart. Adult cardiomyocyte-specific Wdr1 deletion mice (cKO) exhibited cardiac hypertrophy and myocardial fibrosis. Echocardiographic study and electrocardiography revealed impaired contractile function, prolonged QT interval and Tpeak-Tend interval, and abnormal T-wave amplitude in cKO mice. Increased levels of sarcomeric proteins, adherens junction proteins and cofilin, and severe actin filament (F-actin) accumulations were observed in cKO mice heart. Taken together, this finding demonstrates that WDR1 is a critical factor for normal structure and function of adult mouse heart.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cardiomegalia / Proteínas de Microfilamentos Límite: Animals Idioma: En Revista: Gene Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cardiomegalia / Proteínas de Microfilamentos Límite: Animals Idioma: En Revista: Gene Año: 2019 Tipo del documento: Article