Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer.
Oral Dis
; 25(4): 1067-1075, 2019 May.
Article
en En
| MEDLINE
| ID: mdl-30821883
ABSTRACT
OBJECTIVE:
To investigate the risk for second primary cancer in the hypopharynx and esophagus (SPC-HE) among individuals with an initial oral/oropharyngeal cancer. MATERIALS ANDMETHODS:
Mass screening data from Taiwan (2004-2009) included individuals who were ≥18 years old and smoked cigarettes and/or chewed betel quid. Occurrence of SPC-HE was monitored until December 31, 2014. Results were expressed as adjusted relative risk (aRR) and 95% confidence interval (CI).RESULTS:
One hundred and fifty-eight out of 4,494 subjects with oral cancer developed SPC-HE (incidence rate 6.47 per 1,000 person-years). Relative to patients with primary cancers in the lip, the risk of an SPC-HE was higher in patients with primary cancers in oropharynx (aRR 19.98, 95% CI 4.72-84.55), floor of mouth (aRR 12.13, 95% CI 2.67-55.15), and hard palate (aRR 7.31, 95% CI 1.65-32.37), but not in patients with cancers in tongue (aRR 3.67, 95% CI 0.89-15.17) or gum (aRR 3.99, 95% CI 0.92-17.35). Regression analyses also showed the risk of an SPC-HE was greater in alcohol drinkers than those who did not (aRR 1.65, 95% CI 1.10-2.48).CONCLUSIONS:
Compared with the initial cancer in the lip, patients with a cancer in the oropharynx, floor of mouth, and hard palate had a higher risk for the SPC-HE.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Esofágicas
/
Neoplasias de la Boca
/
Carcinoma de Células Escamosas
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Neoplasias Hipofaríngeas
/
Neoplasias Primarias Secundarias
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Adult
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Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Oral Dis
Asunto de la revista:
ODONTOLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Taiwán