A Cell-Level Systems PK-PD Model to Characterize In Vivo Efficacy of ADCs.

Singh, Aman P; Guo, Leiming; Verma, Ashwni; Wong, Gloria Gao-Li; Shah, Dhaval K

Singh, Aman P; Guo, Leiming; Verma, Ashwni; Wong, Gloria Gao-Li; Shah, Dhaval K.

Afiliación

Singh AP; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, 455 Kapoor Hall, Buffalo, New York, NY 14214-8033, USA. amanpree@buffalo.edu.
Guo L; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, 455 Kapoor Hall, Buffalo, New York, NY 14214-8033, USA. leimingg@buffalo.edu.
Verma A; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, 455 Kapoor Hall, Buffalo, New York, NY 14214-8033, USA. ashwnive@buffalo.edu.
Wong GG; Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, NY 14214-8033, USA. gloriawo@buffalo.edu.
Shah DK; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, 455 Kapoor Hall, Buffalo, New York, NY 14214-8033, USA. dshah4@buffalo.edu.

Pharmaceutics ; 11(2)2019 Feb 25.

Article en En | MEDLINE | ID: mdl-30823607

Palabras clave

Antibody-drug conjugates; PK-PD model; Trastuzumab-vc-MMAE; cellular pharmacokinetics; in vivo efficacy; tubulin occupancy; tumor pharmacokinetics

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Pharmaceutics Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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