Fusicoccane Diterpenes from Hypoestes forsskaolii as Heat Shock Protein 90 (Hsp90) Modulators.
J Nat Prod
; 82(3): 539-549, 2019 03 22.
Article
en En
| MEDLINE
| ID: mdl-30839211
ABSTRACT
Ten new (1-10) and six known (11-16) fusicoccane diterpenes were isolated from the roots of Hypoestes forsskaolii. The structural characterization of 1-10 was performed by spectroscopic analysis, including 1D and 2D NMR, ECD, and HRESIMS experiments. From a perspective of obtaining potential Hsp90α inhibitors, the isolates were screened by surface plasmon resonance measurements and their cytotoxic activity was assayed using Jurkat and HeLa cancer cells. Compound 6, 18-hydroxyhypoestenone, was shown to be the most active compound against Hsp90, and its interactions were studied also by biochemical and cellular assays and by molecular docking.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas HSP90 de Choque Térmico
/
Acanthaceae
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Diterpenos
Límite:
Humans
Idioma:
En
Revista:
J Nat Prod
Año:
2019
Tipo del documento:
Article
País de afiliación:
Italia