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Regulatory T cell adaptation in the intestine and skin.
Whibley, Natasha; Tucci, Andrea; Powrie, Fiona.
Afiliación
  • Whibley N; University of Oxford, Kennedy Institute of Rheumatology, Oxford, UK.
  • Tucci A; University of Oxford, Kennedy Institute of Rheumatology, Oxford, UK.
  • Powrie F; University of Oxford, Kennedy Institute of Rheumatology, Oxford, UK. fiona.powrie@kennedy.ox.ac.uk.
Nat Immunol ; 20(4): 386-396, 2019 04.
Article en En | MEDLINE | ID: mdl-30890797
The intestine and skin are distinct microenvironments with unique physiological functions and are continually exposed to diverse environmental challenges. Host adaptation at these sites is an active process that involves interaction between immune cells and tissue cells. Regulatory T cells (Treg cells) play a pivotal role in enforcing homeostasis at barrier surfaces, illustrated by the development of intestinal and skin inflammation in diseases caused by primary deficiency in Treg cells. Treg cells at barrier sites are phenotypically distinct from their lymphoid-organ counterparts, and these 'tissue' signatures often reflect their tissue-adapted function. We discuss current understanding of Treg cell adaptation in the intestine and skin, including unique phenotypes, functions and metabolic demands, and how increased knowledge of Treg cells at barrier sites might guide precision medicine therapies.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piel / Linfocitos T Reguladores / Intestinos Límite: Animals / Humans Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2019 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piel / Linfocitos T Reguladores / Intestinos Límite: Animals / Humans Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2019 Tipo del documento: Article