Adjuvanted influenza vaccine for the Italian elderly in the 2018/19 season: an updated health technology assessment.
Eur J Public Health
; 29(5): 900-905, 2019 10 01.
Article
en En
| MEDLINE
| ID: mdl-30929026
ABSTRACT
BACKGROUND:
The elderly, defined here as subjects aged ≥ 65 years, are among at-risk subjects for whom annual influenza vaccination is recommended. For the 2018/19 season, three vaccine types are available for the elderly in Italy trivalent inactivated vaccine (TIV), adjuvanted TIV (aTIV) and quadrivalent inactivated vaccines (QIV). No health technology assessment (HTA) of seasonal influenza vaccination in the elderly has previously been conducted in Italy.METHODS:
An HTA was conducted in 2017 to analyze the burden of influenza illness, the characteristics, efficacy, safety and cost-effectiveness of available vaccines and the related organizational and ethical implications. This was then contextualized to the 2018/19 influenza season. Comprehensive literature reviews/analyses were performed and a static mathematical model developed in order to address the above issues.RESULTS:
In Italy, influenza is usually less common in the elderly than in other age-classes, but the burden of disease is the highest; >10% of infected elderly subjects develop complications, and about 90% of all influenza-related deaths occur in this age-class. All available vaccines are effective, safe and acceptable from an ethical standpoint. However, aTIV has proved more immunogenic and effective in the elderly. Furthermore, from the third payer's perspective, aTIV is highly cost-effective and cost-saving in comparison with TIV and QIV, respectively. Nevertheless, vaccination coverage needs to be improved.CONCLUSIONS:
According to this HTA, aTIV appeared the vaccine of choice in the elderly. HTA should be reapplied whenever new relevant data become available.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Evaluación de la Tecnología Biomédica
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Vacunas contra la Influenza
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Adyuvantes Inmunológicos
/
Gripe Humana
Tipo de estudio:
Health_technology_assessment
/
Prognostic_studies
Límite:
Aged
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Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Eur J Public Health
Asunto de la revista:
EPIDEMIOLOGIA
/
SAUDE PUBLICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Italia