Mechanisms of Hepatic Cholestatic Drug Injury.
J Clin Transl Hepatol
; 7(1): 86-92, 2019 Mar 28.
Article
en En
| MEDLINE
| ID: mdl-30944824
ABSTRACT
Drug-induced cholestasis represents a form of drug-induced liver disease that can lead to severe impairment of liver function. Numerous drugs have been shown to cause cholestasis and consequently bile duct toxicity. However, there is still lack of therapeutic tools that can prevent progression to advanced stages of liver injury. This review focuses on the various pathological mechanisms by which drugs express their hepatotoxic effects, as well as consequences of increased bile acid and toxin accumulation in the hepatocytes.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
J Clin Transl Hepatol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Croacia