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The Relevance of Vascular Endothelial Growth Factor, Hypoxia Inducible Factor-1 Alpha, and Clusterin in Carotid Plaque Instability.
Basic, Jelena; Stojkovic, Stefan; Assadian, Afshin; Rauscher, Sabine; Duschek, Nikolaus; Kaun, Christoph; Wojta, Johann; Falkensammer, Jürgen.
Afiliación
  • Basic J; Department of Vascular and Endovascular Surgery, Wilhelminenspital, Vienna, Austria; 2nd Medical Department with Cardiology and Intensive Care Medicine, KA Rudolfstiftung, Vienna, Austria. Electronic address: jelenazbasic@gmail.com.
  • Stojkovic S; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.
  • Assadian A; Department of Vascular and Endovascular Surgery, Wilhelminenspital, Vienna, Austria.
  • Rauscher S; Core Facility Imaging, Medical University of Vienna, Vienna, Austria.
  • Duschek N; Department of Dermatology and Venereology, University Hospital St. Poelten, St. Poelten, Austria.
  • Kaun C; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.
  • Wojta J; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute, Cluster for Cardiovascular Research, Vienna, Austria.
  • Falkensammer J; Department of Vascular and Endovascular Surgery, Wilhelminenspital, Vienna, Austria.
J Stroke Cerebrovasc Dis ; 28(6): 1540-1545, 2019 Jun.
Article en En | MEDLINE | ID: mdl-30952532
BACKGROUND: Stroke is one of the leading causes of morbidity and mortality. Thromboembolism, as a major cause of carotid artery-related stroke, can be caused by plaque rupture which is associated with neoangiogenesis within the carotid plaque. AIM: We sought to investigate a possible correlation between angiogenesis-related factors and preoperative neurological manifestations in patients with internal carotid artery stenosis, for a better understanding of thromboembolism in internal carotid artery stenosis-related stroke. METHODS: This study included 54 patients (asymptomatic, n = 20 and symptomatic, n = 34) undergoing carotid endarterectomy for high-grade internal carotid artery stenosis. In the retrieved carotid plaques, angiogenesis-related factors (vascular endothelial growth factor [VEGF], hypoxia inducible factor-1 alpha [HIF-1α], and Clusterin) were measured by immunohistochemistry and quantified by real-time polymerase chain reaction. RESULTS: We demonstrated the expression of VEGF, HIF-1α, and Clusterin by endothelial cells and smooth muscle cells in the carotid plaques. Noteworthy, mRNA VEGF levels were .7-fold higher in symptomatic patients (P = .017) compared to asymptomatic patients. In contrast, mRNA Clusterin levels were 1.8-fold lower (P = .021). Levels of mRNA HIF-1α were 1.5-fold higher in asymptomatic patients, but no statistical significance was reached between the 2 groups. CONCLUSIONS: Our results show an association between VEGF and Clusterin and neurological symptoms of patients with high-grade carotid artery stenosis.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Arteria Carótida Interna / Estenosis Carotídea / Factor A de Crecimiento Endotelial Vascular / Subunidad alfa del Factor 1 Inducible por Hipoxia / Clusterina / Placa Aterosclerótica Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Stroke Cerebrovasc Dis Asunto de la revista: ANGIOLOGIA / CEREBRO Año: 2019 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Arteria Carótida Interna / Estenosis Carotídea / Factor A de Crecimiento Endotelial Vascular / Subunidad alfa del Factor 1 Inducible por Hipoxia / Clusterina / Placa Aterosclerótica Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Stroke Cerebrovasc Dis Asunto de la revista: ANGIOLOGIA / CEREBRO Año: 2019 Tipo del documento: Article