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Decreased Tenofovir Diphosphate Concentrations in a Transgender Female Cohort: Implications for Human Immunodeficiency Virus Preexposure Prophylaxis.
Cottrell, Mackenzie L; Prince, Heather M A; Schauer, Amanda P; Sykes, Craig; Maffuid, Kaitlyn; Poliseno, Amanda; Chun, Tae-Wook; Huiting, Erin; Stanczyk, Frank Z; Peery, Anne F; Dellon, Evan S; Adams, Jessica L; Gay, Cindy; Kashuba, Angela D M.
Afiliación
  • Cottrell ML; Eshelman School of Pharmacy, Division of Pharmacotherapy and Experimental Therapeutics.
  • Prince HMA; School of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill.
  • Schauer AP; Eshelman School of Pharmacy, Division of Pharmacotherapy and Experimental Therapeutics.
  • Sykes C; Eshelman School of Pharmacy, Division of Pharmacotherapy and Experimental Therapeutics.
  • Maffuid K; Eshelman School of Pharmacy, Division of Pharmacotherapy and Experimental Therapeutics.
  • Poliseno A; Eshelman School of Pharmacy, Division of Pharmacotherapy and Experimental Therapeutics.
  • Chun TW; HIV Immunovirology Unit, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.
  • Huiting E; HIV Immunovirology Unit, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.
  • Stanczyk FZ; Keck School of Medicine, University of Southern California, Los Angeles.
  • Peery AF; School of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill.
  • Dellon ES; School of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill.
  • Adams JL; Philadelphia College of Pharmacy, University of the Sciences, Pennsylvania.
  • Gay C; Cooper University Hospital Early Intervention Program, Camden, New Jersey.
  • Kashuba ADM; School of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill.
Clin Infect Dis ; 69(12): 2201-2204, 2019 11 27.
Article en En | MEDLINE | ID: mdl-30963179
ABSTRACT
Feminizing hormone therapy (FHT) may interact with human immunodeficiency virus preexposure prophylaxis (PrEP). We found that transgender women who took FHT exhibited a 7-fold lower rectal tissue ratio of PrEP's active metabolites vs competing deoxynucleotides compared to cisgender women and men (P = .03) that inversely correlated with estradiol (ρ = -0.79; P < .05). Thus, FHT may negatively impact PrEP efficacy. Clinical Trials Registration . NCT02983110.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Organofosfatos / Adenina / Infecciones por VIH / VIH / Fármacos Anti-VIH / Personas Transgénero / Profilaxis Pre-Exposición Tipo de estudio: Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Organofosfatos / Adenina / Infecciones por VIH / VIH / Fármacos Anti-VIH / Personas Transgénero / Profilaxis Pre-Exposición Tipo de estudio: Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2019 Tipo del documento: Article