Acid Fluorides in Transition-Metal Catalysis: A Good Balance between Stability and Reactivity.
Angew Chem Int Ed Engl
; 58(21): 6814-6817, 2019 May 20.
Article
en En
| MEDLINE
| ID: mdl-30964591
ABSTRACT
Several recent reports outlined the singular reactivity of acid fluorides as excellent electrophiles in transition-metal catalysis. These species undergo oxidative addition of the metal into the C-F bond; then, retention or release of the CO moiety can occur and be controlled by tuning the catalytic system and the reaction parameters. Acid fluorides, which can be derived from carboxylic acids, show good stability and high reactivity in a wide range of possible functionalizations with nucleophiles. Their use provides an interesting alternative to that of the parent carboxylic acid derivatives (acid chlorides, esters, amides, acids, or aldehydes).
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1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Año:
2019
Tipo del documento:
Article
País de afiliación:
Francia