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Intranasal administration of oxytocin decreases task-related aggressive responses in healthy young males.
Berends, Youri R; Tulen, Joke H M; Wierdsma, André I; van Pelt, Johannes; Feldman, Ruth; Zagoory-Sharon, Orna; de Rijke, Yolanda B; Kushner, Steven A; van Marle, Hjalmar J C.
Afiliación
  • Berends YR; Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, The Netherlands; Fivoor, FPC de Kijvelanden, Poortugaal, The Netherlands. Electronic address: y.berends@erasmusmc.nl.
  • Tulen JHM; Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, The Netherlands.
  • Wierdsma AI; Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, The Netherlands.
  • van Pelt J; Noordwest Ziekenhuisgroep, Alkmaar, The Netherlands.
  • Feldman R; Interdisciplinary Center, Herzliya, Israel.
  • Zagoory-Sharon O; Interdisciplinary Center, Herzliya, Israel.
  • de Rijke YB; Department of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, The Netherlands.
  • Kushner SA; Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, The Netherlands.
  • van Marle HJC; Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, The Netherlands; Fivoor, FPC de Kijvelanden, Poortugaal, The Netherlands.
Psychoneuroendocrinology ; 106: 147-154, 2019 08.
Article en En | MEDLINE | ID: mdl-30981088
Aggression and distrust are often challenging problems in mental health treatment. Converging evidence reveals that oxytocin increases trust in social interactions and decreases fear of social betrayal. However, oxytocin has also been associated with protective behavior and, as such, might increase defensive aggressive reactions. In this randomized double-blind, placebo-controlled study, the effects of intranasal oxytocin (32IU) on task-related aggressive responses were measured using the Point Subtraction Aggression Paradigm (PSAP). Fifty-seven healthy males were enrolled and randomized to oxytocin (N = 30) or placebo (n = 27). Salivary oxytocin, cortisol and testosterone were measured serially prior to the intervention, and then before and after the PSAP, to evaluate the effects of oxytocin administration on hormonal functioning in relation to aggression. In addition, oxytocin was measured in urine collected directly after the experimental task, reflecting the 2 h period after oxytocin or placebo administration. The proportion of aggressive responses to the PSAP was significantly lower in participants receiving oxytocin versus placebo (ß= -0.46, P = 0.01). No significant effect of oxytocin was found regarding defensive reactions. Urinary oxytocin was negatively associated with the proportion of aggressive responses to the PSAP in both the oxytocin and the placebo group (ß= -0.02, P < 0.01), suggesting that higher levels of urinary oxytocin corresponded with reduced aggressive responding. Our results indicate that oxytocin administration reduces aggressive behavior in healthy young men. Moreover, increased endogenous urinary oxytocin is associated with less aggressive responding. Taken together, these findings suggest that oxytocin signaling has a causal influence on aggressive behavior.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oxitocina / Agresión Tipo de estudio: Clinical_trials Límite: Adolescent / Adult / Humans / Male Idioma: En Revista: Psychoneuroendocrinology Año: 2019 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oxitocina / Agresión Tipo de estudio: Clinical_trials Límite: Adolescent / Adult / Humans / Male Idioma: En Revista: Psychoneuroendocrinology Año: 2019 Tipo del documento: Article