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Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.
Zak, Mark; Hanan, Emily J; Lupardus, Patrick; Brown, David G; Robinson, Colin; Siu, Michael; Lyssikatos, Joseph P; Romero, F Anthony; Zhao, Guiling; Kellar, Terry; Mendonca, Rohan; Ray, Nicholas C; Goodacre, Simon C; Crackett, Peter H; McLean, Neville; Hurley, Christopher A; Yuen, Po-Wai; Cheng, Yun-Xing; Liu, Xiongcai; Liimatta, Marya; Kohli, Pawan Bir; Nonomiya, Jim; Salmon, Gary; Buckley, Gerry; Lloyd, Julia; Gibbons, Paul; Ghilardi, Nico; Kenny, Jane R; Johnson, Adam.
Afiliación
  • Zak M; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: mzak@gene.com.
  • Hanan EJ; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Lupardus P; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Brown DG; Charles River Laboratories, 8-9 Spire Green Centre, Harlow, Essex CM19 5TR, United Kingdom.
  • Robinson C; Charles River Laboratories, 8-9 Spire Green Centre, Harlow, Essex CM19 5TR, United Kingdom.
  • Siu M; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Lyssikatos JP; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Romero FA; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Zhao G; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Kellar T; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Mendonca R; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Ray NC; Charles River Laboratories, 8-9 Spire Green Centre, Harlow, Essex CM19 5TR, United Kingdom.
  • Goodacre SC; Charles River Laboratories, 8-9 Spire Green Centre, Harlow, Essex CM19 5TR, United Kingdom.
  • Crackett PH; Charles River Laboratories, 8-9 Spire Green Centre, Harlow, Essex CM19 5TR, United Kingdom.
  • McLean N; Charles River Laboratories, 8-9 Spire Green Centre, Harlow, Essex CM19 5TR, United Kingdom.
  • Hurley CA; Charles River Laboratories, 8-9 Spire Green Centre, Harlow, Essex CM19 5TR, United Kingdom.
  • Yuen PW; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, PR China.
  • Cheng YX; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, PR China.
  • Liu X; Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, PR China.
  • Liimatta M; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Kohli PB; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Nonomiya J; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Salmon G; Charles River Laboratories, 8-9 Spire Green Centre, Harlow, Essex CM19 5TR, United Kingdom.
  • Buckley G; Charles River Laboratories, 8-9 Spire Green Centre, Harlow, Essex CM19 5TR, United Kingdom.
  • Lloyd J; Charles River Laboratories, 8-9 Spire Green Centre, Harlow, Essex CM19 5TR, United Kingdom.
  • Gibbons P; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Ghilardi N; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Kenny JR; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Johnson A; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Bioorg Med Chem Lett ; 29(12): 1522-1531, 2019 06 15.
Article en En | MEDLINE | ID: mdl-30981576
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Interleucina-13 / Dermatitis Atópica / Janus Quinasa 1 / Janus Quinasa 2 Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Interleucina-13 / Dermatitis Atópica / Janus Quinasa 1 / Janus Quinasa 2 Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article