Prognostic Significance of Heart Rate Turbulence Parameters in Patients with Noncompaction Cardiomyopathy.
Cardiology
; 142(1): 56-62, 2019.
Article
en En
| MEDLINE
| ID: mdl-30982054
ABSTRACT
BACKGROUND:
Noncompaction cardiomyopathy (NC) is a rare congenital heart disease characterized by progressive heart failure and life-threatening arrhythmias. Heart rate turbulence (HRT) has been defined as a noninvasive prognostic method to reveal the cardiac death risk in high-risk patients.OBJECTIVES:
We aimed to assess the cardiac autonomic functions and their relations to the mortality in NC patients.METHODS:
A total of 60 NC patients and 70 healthy controls were included in this study. All participants underwent 24-h Holter recording to assess the HRT parameters, included turbulence onset (TO), turbulence slope (TS), standard deviation of NN intervals of all normal beats (SDNN) and mean RR interval.RESULTS:
NC patients had higher levels of TO than the control group (0.43 ± 4.66% vs. -1.82 ± 2.19%, p = 0.024), but the TS levels of NC patients were lower than those of the control group (3.43 ± 3.28 vs. 4.94 ± 2.86 ms/RR, p = 0.024). Thirteen patients died during follow-up (mean 83.3 ± 32.5 months). TS was the strongest univariate mortality predictor (hazard ratio 10.01 [95% CI 2.22-42.52]; p = 0.004) in univariate Cox regression analysis. In multivariate analysis, LVEF ≤0.40 and TS ≤2.5 ms/RR interval were the only independent predictors of mortality (hazard ratio 5.29; p = 0.004, hazard ratio 13.45; p = 0.001, respectively).CONCLUSIONS:
Patients with NC showed abnormal HRV and HRT parameters when compared to healthy subjects. Furthermore, impaired HRT reaction in NC is an independent predictor of mortality.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Arritmias Cardíacas
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Cardiopatías Congénitas
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Frecuencia Cardíaca
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Cardiology
Año:
2019
Tipo del documento:
Article
País de afiliación:
Chipre