Chemical constituents from Vietnamese mangrove Calophyllum inophyllum and their anti-inflammatory effects.
Bioorg Chem
; 88: 102921, 2019 07.
Article
en En
| MEDLINE
| ID: mdl-30991191
ABSTRACT
In a search for anti-inflammatory activity in resources from Vietnamese mangroves, we found that a methanolic extract from the leaves of Calophyllum inophyllum (CIL) showed significant anti-inflammatory effects in vitro. Using various chromatographic techniques, we subsequently isolated 12 compounds (1-12) from a methanolic extract of CIL, including two novel compounds (1-2). The inhibitory effects of these compounds on lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 cells were also evaluated. Compound 1 significantly suppressed NO production (IC50â¯=â¯2.44⯱â¯0.88⯵M), the secretion of pro-inflammatory cytokines (including interleukin-1 beta and tumor necrosis factor alpha), and the expression of inducible nitric oxide synthase through downregulation of nuclear factor-kappa-B signaling cascades. These results suggest that C. inophyllum leaves might be a useful resource for the development of drugs for the treatment of inflammation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Triterpenos
/
Calophyllum
/
Antiinflamatorios
Límite:
Animals
Idioma:
En
Revista:
Bioorg Chem
Año:
2019
Tipo del documento:
Article