[Molecular mechanism of vascular remodeling in hypertension and Chinese medicine intervention].
Sheng Li Xue Bao
; 71(2): 235-247, 2019 Apr 25.
Article
en Zh
| MEDLINE
| ID: mdl-31008483
ABSTRACT
Vascular remodeling is a significant pathological characteristic of hypertension, which is regulated by complex regulatory networks. The vascular remodeling may be adaptive initially, however it becomes maladaptive and decompensation eventually and further compromises target organ function, leading to hypertensive cardiovascular complications. This review focuses on the role and mechanisms of vascular remodeling in the pathogenesis and progression of hypertension and its complications. Moreover, the strategies of syndrome differentiation of traditional Chinese medicine application provide clinical and theoretical evidences for hypertensive vascular remodeling therapy. A better understanding of underlying signaling pathways, therapeutic targets in vascular remodeling, as well as screening of active ingredients from traditional Chinese medicine may be able to provide some effective approaches for vascular protection in hypertensive diseases.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Remodelación Vascular
/
Hipertensión
/
Medicina Tradicional China
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
Zh
Revista:
Sheng Li Xue Bao
Año:
2019
Tipo del documento:
Article
País de afiliación:
China