Amyotrophic lateral sclerosis mutant TDP-43 may cause synaptic dysfunction through altered dendritic spine function.

Jiang, Tongcui; Handley, Emily; Brizuela, Mariana; Dawkins, Edgar; Lewis, Katherine E A; Clark, Rosemary M; Dickson, Tracey C; Blizzard, Catherine A

Jiang, Tongcui; Handley, Emily; Brizuela, Mariana; Dawkins, Edgar; Lewis, Katherine E A; Clark, Rosemary M; Dickson, Tracey C; Blizzard, Catherine A.

Afiliación

Jiang T; Menzies Institute for Medical Research, University of Tasmania, Medical Sciences Precinct, 17 Liverpool Street, Hobart, TAS 7000, Australia.
Handley E; Menzies Institute for Medical Research, University of Tasmania, Medical Sciences Precinct, 17 Liverpool Street, Hobart, TAS 7000, Australia.
Brizuela M; Menzies Institute for Medical Research, University of Tasmania, Medical Sciences Precinct, 17 Liverpool Street, Hobart, TAS 7000, Australia.
Dawkins E; Menzies Institute for Medical Research, University of Tasmania, Medical Sciences Precinct, 17 Liverpool Street, Hobart, TAS 7000, Australia.
Lewis KEA; Menzies Institute for Medical Research, University of Tasmania, Medical Sciences Precinct, 17 Liverpool Street, Hobart, TAS 7000, Australia.
Clark RM; Menzies Institute for Medical Research, University of Tasmania, Medical Sciences Precinct, 17 Liverpool Street, Hobart, TAS 7000, Australia.
Dickson TC; Menzies Institute for Medical Research, University of Tasmania, Medical Sciences Precinct, 17 Liverpool Street, Hobart, TAS 7000, Australia.
Blizzard CA; Menzies Institute for Medical Research, University of Tasmania, Medical Sciences Precinct, 17 Liverpool Street, Hobart, TAS 7000, Australia Catherine.Blizzard@utas.edu.au.

Dis Model Mech ; 12(5)2019 05 17.

Article en En | MEDLINE | ID: mdl-31036551

Asunto(s)

Esclerosis Amiotrófica Lateral/genética; Proteínas de Unión al ADN/genética; Espinas Dendríticas/patología; Mutación/genética; Sinapsis/patología; Animales; Axones/metabolismo; Axones/patología; Corteza Cerebral/patología; Espinas Dendríticas/metabolismo; Humanos; Ratones Transgénicos; Sinapsis/metabolismo

Palabras clave

AMPA; Dendrite spine; Excitability; Synapse; TDP-43

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sinapsis / Espinas Dendríticas / Proteínas de Unión al ADN / Esclerosis Amiotrófica Lateral / Mutación Límite: Animals / Humans Idioma: En Revista: Dis Model Mech Asunto de la revista: MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Australia

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