Cellular functions of long noncoding RNAs.

Yao, Run-Wen; Wang, Yang; Chen, Ling-Ling

Yao, Run-Wen; Wang, Yang; Chen, Ling-Ling.

Afiliación

Yao RW; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Wang Y; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Chen LL; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. linglingchen@s

Nat Cell Biol ; 21(5): 542-551, 2019 05.

Article en En | MEDLINE | ID: mdl-31048766

RESUMEN

A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential, are transcribed from the mammalian genome. They are emerging as important regulators in gene expression networks by controlling nuclear architecture and transcription in the nucleus and by modulating mRNA stability, translation and post-translational modifications in the cytoplasm. In this Review, we highlight recent progress in cellular functions of lncRNAs at the molecular level in mammalian cells.

Asunto(s)

Fenómenos Fisiológicos Celulares/genética; Genoma/genética; Biosíntesis de Proteínas/genética; ARN Largo no Codificante/genética; Animales; Redes Reguladoras de Genes/genética; Humanos; Procesamiento Proteico-Postraduccional/genética; Estabilidad del ARN/genética

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Biosíntesis de Proteínas / Fenómenos Fisiológicos Celulares / Genoma / ARN Largo no Codificante Límite: Animals / Humans Idioma: En Revista: Nat Cell Biol Año: 2019 Tipo del documento: Article País de afiliación: China

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