Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus.
Science
; 364(6440): 578-583, 2019 05 10.
Article
en En
| MEDLINE
| ID: mdl-31073064
ABSTRACT
Young adult-born granule cells (abGCs) in the dentate gyrus (DG) have a profound impact on cognition and mood. However, it remains unclear how abGCs distinctively contribute to local DG information processing. We found that the actions of abGCs in the DG depend on the origin of incoming afferents. In response to lateral entorhinal cortex (LEC) inputs, abGCs exert monosynaptic inhibition of mature granule cells (mGCs) through group II metabotropic glutamate receptors. By contrast, in response to medial entorhinal cortex (MEC) inputs, abGCs directly excite mGCs through N-methyl-d-aspartate receptors. Thus, a critical function of abGCs may be to regulate the relative synaptic strengths of LEC-driven contextual information versus MEC-driven spatial information to shape distinct neural representations in the DG.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Corteza Entorrinal
/
Giro Dentado
/
Hipocampo
/
Neuronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Año:
2019
Tipo del documento:
Article