Inhibition of mTOR by Rapamycin Aggravates Corneal Epithelial Stem Cell Deficiency by Upregulating Inflammatory Response.

Park, Jong Woo; Ko, Jung Hwa; Kim, Bo Hee; Ryu, Jin Suk; Kim, Hyun Ji; Kim, Mee Kum; Oh, Joo Youn

Park, Jong Woo; Ko, Jung Hwa; Kim, Bo Hee; Ryu, Jin Suk; Kim, Hyun Ji; Kim, Mee Kum; Oh, Joo Youn.

Afiliación

Park JW; Laboratory of Ocular Regenerative Medicine and Immunology, Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea.
Ko JH; Laboratory of Ocular Regenerative Medicine and Immunology, Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea.
Kim BH; Department of Ophthalmology, Seoul National University Hospital, Seoul, South Korea.
Ryu JS; Laboratory of Ocular Regenerative Medicine and Immunology, Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea.
Kim HJ; Laboratory of Ocular Regenerative Medicine and Immunology, Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea.
Kim MK; Laboratory of Ocular Regenerative Medicine and Immunology, Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea.
Oh JY; Department of Ophthalmology, Seoul National University Hospital, Seoul, South Korea.

Stem Cells ; 37(9): 1212-1222, 2019 09.

Article en En | MEDLINE | ID: mdl-31102490

Asunto(s)

Córnea/citología; Células Epiteliales/metabolismo; Inflamación/metabolismo; Sirolimus/farmacología; Células Madre/metabolismo; Serina-Treonina Quinasas TOR/antagonistas & inhibidores; Animales; Apoptosis/efectos de los fármacos; Apoptosis/genética; Células Cultivadas; Córnea/metabolismo; Citocinas/genética; Citocinas/metabolismo; Expresión Génica/efectos de los fármacos; Humanos; Inmunosupresores/farmacología; Inflamación/genética; Masculino; Ratones; Ratones Endogámicos BALB C; Ratones Endogámicos C57BL; Células Madre/efectos de los fármacos; Serina-Treonina Quinasas TOR/metabolismo

Palabras clave

Apoptosis; Corneal epithelial stem cell; Inflammation; Interleukin-10; Mammalian target of rapamycin; Rapamycin

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Madre / Córnea / Sirolimus / Células Epiteliales / Serina-Treonina Quinasas TOR / Inflamación Límite: Animals / Humans / Male Idioma: En Revista: Stem Cells Año: 2019 Tipo del documento: Article País de afiliación: Corea del Sur

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