Anti-Ku syndrome with elevated CK and anti-Ku syndrome with anti-dsDNA are two distinct entities with different outcomes.
Ann Rheum Dis
; 78(8): 1101-1106, 2019 08.
Article
en En
| MEDLINE
| ID: mdl-31126956
ABSTRACT
OBJECTIVE:
To refine the spectrum of anti-Ku-associated disease, a condition that is equivocally described by current diagnostic criteria for connective tissue diseases.METHODS:
Among 42 consecutive patients harbouring anti-Ku antibodies, subgroups with similar phenotypes and prognosis were delineated without an a priori diagnosis using hierarchical clustering analysis of the cumulative clinico-biological features recorded during the follow-up. Features present at baseline that most efficiently predicted the outcomes were then identified using a sensitivity-specificity sum maximisation approach.RESULTS:
Clinico-biological features were clustered into three groups. Glomerulonephritis and ILD, the two fatal complications in this cohort, were unequally distributed between the three clusters that additionally differed on six clinico-biological features.Among features present at baseline, elevated serum level of creatine kinase (CK) and anti-dsDNA antibodies were generally mutually exclusive and most efficiently predicted the cluster belonging at last follow-up. Anti-Ku patients with elevated CK had a 22-fold higher risk of ILD while anti-Ku patients with anti-dsDNA antibodies had a 13-fold higher risk of glomerulonephritisCONCLUSION:
"Anti-Ku with elevated CK" syndrome and "anti-Ku with anti-dsDNA" syndrome represent two distinct entities that are important to recognise in order to best tailor patient care.Palabras clave
Anti-Ku antibodies; Antisynthetase; Classification; Dermatomyositis; Inflammatory myopathies; Inflammatory myopathy; Inflammatory skeletal muscle; Interstitial lung disease; Mixed connective tissue disease; Myositis; Necrotizing myopathy; Polymyositis; Systemic lupus erythematosus; Systemic sclerosis; Undifferentiated connective tissue disease; autoantibodies; autoimmune diseases; autoimmunity; necrotizing myopathies; scleroderma
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
/
Enfermedades Autoinmunes
/
Enfermedades Pulmonares Intersticiales
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Artralgia
/
Creatina Quinasa
/
Glomerulonefritis
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Female
/
Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
Ann Rheum Dis
Año:
2019
Tipo del documento:
Article
País de afiliación:
Francia