Your browser doesn't support javascript.
loading
Size and Flexibility Define the Inhibition of the H3N2 Influenza Endonuclease Enzyme by Calix[n]arenes.
Tauran, Yannick; Cerón-Carrasco, José Pedro; Rhimi, Moez; Perret, Florent; Kim, Beomjoon; Collard, Dominique; Coleman, Anthony W; Pérez-Sánchez, Horacio.
Afiliación
  • Tauran Y; Laboratoire Multimatériaux et Interfaces CNRS UMR 5615, Université Lyon 1, 69622 Villeurbanne, France. yannick.tauran@univ-lyon1.fr.
  • Cerón-Carrasco JP; Laboratory for Integrated Micro-Mechatronic Systems (LIMMS)/CNRS-IIS UMI 2820, Institute of Industrial Science, The University of Tokyo, Tokyo 153-8505, Japan. yannick.tauran@univ-lyon1.fr.
  • Rhimi M; Bioinformatics and High Performance Computing (BIO-HPC) Research Group, Universidad Católica de Murcia (UCAM), 30107 Murcia, Spain. jpceron@ucam.edu.
  • Perret F; Institut National de la Recherche Agronomique (INRA), UMR 1319 Micalis, F-78350 Jouy-en-Josas, France. moez.rhimi@jouy.inra.fr.
  • Kim B; Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, CNRS UMR 5246, Université Lyon 1, 69622 Villeurbanne, France. florent.perret@univ-lyon1.fr.
  • Collard D; Laboratory for Integrated Micro-Mechatronic Systems (LIMMS)/CNRS-IIS UMI 2820, Institute of Industrial Science, The University of Tokyo, Tokyo 153-8505, Japan. bjoonkim@iis.u-tokyo.ac.jp.
  • Coleman AW; Centre for Interdisciplinary Research on Micro-Nano Methods (CIRMM), Institute of Industrial Science, University of Tokyo, Tokyo 153-8505, Japan. bjoonkim@iis.u-tokyo.ac.jp.
  • Pérez-Sánchez H; Université Lille, CNRS, Centrale Lille, Institut Supérieur de l'Electronique et du Numérique (ISEN), University Valenciennes, UMR 8520-IEMN, F59000 Lille, France. collard@iis.u-tokyo.ac.jp.
Antibiotics (Basel) ; 8(2)2019 Jun 03.
Article en En | MEDLINE | ID: mdl-31163674
ABSTRACT
Inhibition of H3N2 influenza PA endonuclease activity by a panel of anionic calix[n]arenes and ß-cyclodextrin sulfate has been studied. The joint experimental and theoretical results reveal that the larger, more flexible and highly water-soluble sulfonato-calix[n]arenes have high inhibitory activity, with para-sulfonato-calix[8]arene, SC8, having an IC50 value of 6.4 µM. Molecular docking calculations show the SC8 can interact at both the polyanion binding site and also the catalytic site of H3N2 influenza PA endonuclease.
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Antibiotics (Basel) Año: 2019 Tipo del documento: Article País de afiliación: Francia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Antibiotics (Basel) Año: 2019 Tipo del documento: Article País de afiliación: Francia