Protein painting, an optimized MS-based technique, reveals functionally relevant interfaces of the PD-1/PD-L1 complex and the YAP2/ZO-1 complex.

Haymond, Amanda; Dey, Douglass; Carter, Rachel; Dailing, Angela; Nara, Vaishnavi; Nara, Pranavi; Venkatayogi, Sravani; Paige, Mikell; Liotta, Lance; Luchini, Alessandra

Haymond, Amanda; Dey, Douglass; Carter, Rachel; Dailing, Angela; Nara, Vaishnavi; Nara, Pranavi; Venkatayogi, Sravani; Paige, Mikell; Liotta, Lance; Luchini, Alessandra.

Afiliación

Haymond A; Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia 20110 ahaymond@gmu.edu.
Dey D; Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia 20110.
Carter R; Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia 20110.
Dailing A; Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia 20110.
Nara V; Thomas Jefferson High School for Science and Technology, Alexandria, Virginia 22312.
Nara P; University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Venkatayogi S; Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia 20110.
Paige M; Department of Chemistry and Biochemistry, George Mason University, Fairfax, Virginia 20110.
Liotta L; Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia 20110.
Luchini A; Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia 20110.

J Biol Chem ; 294(29): 11180-11198, 2019 07 19.

Article en En | MEDLINE | ID: mdl-31167787

Asunto(s)

Proteínas Adaptadoras Transductoras de Señales/metabolismo; Antígeno B7-H1/metabolismo; Espectrometría de Masas/métodos; Receptor de Muerte Celular Programada 1/metabolismo; Factores de Transcripción/metabolismo; Proteína de la Zonula Occludens-1/metabolismo; Aminoácidos/metabolismo; Compuestos Azo/metabolismo; Sitios de Unión; Humanos; Interacciones Hidrofóbicas e Hidrofílicas; Unión Proteica; Proteínas Señalizadoras YAP

Palabras clave

PD-L1; Yes-associated protein (YAP); ZO-1; cell signaling; immune checkpoint inhibitor; mass spectrometry (MS); programmed cell death protein 1 (PD-1); protein painting; protein-protein interaction; structural biology

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Espectrometría de Masas / Factores de Transcripción / Proteínas Adaptadoras Transductoras de Señales / Antígeno B7-H1 / Receptor de Muerte Celular Programada 1 / Proteína de la Zonula Occludens-1 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2019 Tipo del documento: Article

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