[Desensitization Therapy for Osimertinib in Patients Who Developed Toxic Erythema - Two Case Reports].
Gan To Kagaku Ryoho
; 46(5): 961-963, 2019 May.
Article
en Ja
| MEDLINE
| ID: mdl-31189826
ABSTRACT
We encountered 2 cases of T790M-positive non-small cell lung cancer in patients who developed toxic erythema within a week after initiation of osimertinib(80mg/day)therapy. Since osimertinib was regarded as the suspected drug, we adminis- tered desensitization therapy for osimertinib at an initial dose of 10mg/day. During the process of dose escalation, slight eruption and flare were observed, but we were able to provide appropriate treatment. Osimertinib therapy was continued and conferred tumor reduction in both cases. We report the clinical course and suggest that desensitization therapy is an alternative therapy for patients who present with drug-induced allergic reaction.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Acrilamidas
/
Carcinoma de Pulmón de Células no Pequeñas
/
Eritema
/
Compuestos de Anilina
/
Neoplasias Pulmonares
Límite:
Humans
Idioma:
Ja
Revista:
Gan To Kagaku Ryoho
Año:
2019
Tipo del documento:
Article