Epidemiology of acute coronary syndrome co-existent with allergic/hypersensitivity/anaphylactic reactions (Kounis syndrome) in the United States: A nationwide inpatient analysis.
Int J Cardiol
; 292: 35-38, 2019 10 01.
Article
en En
| MEDLINE
| ID: mdl-31204069
ABSTRACT
BACKGROUND:
The nationwide epidemiological data on Kounis Syndrome (KS), still remains indistinct in the United States (US) after it was first reported in 1991.METHODS:
We assessed the prevalence of KS among patients primarily hospitalized for allergic/hypersensitivity/anaphylactic reactions. We then compared baseline demographics, comorbidities, and outcomes of KS with patients with only allergic/hypersensitivity/anaphylactic reactions using the National Inpatient Sample, 2007-2014.RESULTS:
The cohort comprised of 235,420 patients primarily hospitalized with allergy/hypersensitivity/anaphylactic reactions. Of these, 2616 [1.1%; 0.2% unstable angina, 0.2% ST-elevation myocardial infarction & 0.7% non-ST-elevation myocardial infarction] patients experienced ACS and were identified as having KS. Patients with KS were older (mean 65.9⯱â¯14.1 vs. 57.2⯱â¯17.8â¯yrs), more often White (71.1% vs. 58.6%), male (46.4% vs. 39.9%) and Medicare enrollees (58.9% vs. 41.5%) admitted non-electively (96.8% vs. 95.3%) as compared to non-KS group (pâ¯<â¯0.001). The hospitalizations with KS demonstrated higher all-cause in-hospital mortality (7.0% vs. 0.4%, pâ¯<â¯0.001), prolonged hospitalization stay (mean 5.8⯱â¯6.0 vs. 3.0⯱â¯3.9â¯days, pâ¯<â¯0.001), higher hospitalization charges ($52,656 vs. $20,487, pâ¯<â¯0.001) and more frequent transfers to other facilities. The rates of stroke (1.0% vs. 0.2%), arrhythmias (30.4% vs. 12.4%), venous thromboembolism (1.6% vs. 1.0%), and diagnostic and therapeutic coronary interventions were also found to be significantly higher in patients with KS (pâ¯<â¯0.05). Patients with KS had increased odds of in-hospital mortality [unadjusted OR 18.52; 95% CI 15.74-21.80, pâ¯<â¯0.001 & adjusted OR 9.74, 95% CI 8.08-11.76, pâ¯<â¯0.001] compared to non-KS group.CONCLUSIONS:
Overall US prevalence of KS among patients hospitalized for allergic/hypersensitivity/anaphylactic reactions is 1.1% with a subsequent all-cause inpatient mortality rate of 7.0%.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Síndrome de Kounis
Tipo de estudio:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
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Screening_studies
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Int J Cardiol
Año:
2019
Tipo del documento:
Article