Silencing FUNDC1 alleviates chronic obstructive pulmonary disease by inhibiting mitochondrial autophagy and bronchial epithelium cell apoptosis under hypoxic environment.

Wen, Wen; Yu, Guoqing; Liu, Wei; Gu, Lei; Chu, Jiahui; Zhou, Xiao; Liu, Yuebin; Lai, Guoxiang

Wen, Wen; Yu, Guoqing; Liu, Wei; Gu, Lei; Chu, Jiahui; Zhou, Xiao; Liu, Yuebin; Lai, Guoxiang.

Afiliación

Wen W; Department of Respiratory and Critical Care Medicine, Fuzhou General Hospital of Fujian Medical University, Dongfang Hospital of Xiamen University, 900th Hospital of the Joint Logistics Support Force, Fuzhou, P.R. China.
Yu G; Department of Respiratory and Critical Care Medicine, Fuzhou General Hospital of Fujian Medical University, Dongfang Hospital of Xiamen University, 900th Hospital of the Joint Logistics Support Force, Fuzhou, P.R. China.
Liu W; Department of Respiratory and Critical Care Medicine, Fuzhou General Hospital of Fujian Medical University, Dongfang Hospital of Xiamen University, 900th Hospital of the Joint Logistics Support Force, Fuzhou, P.R. China.
Gu L; Department of Respiratory and Critical Care Medicine, Fuzhou General Hospital of Fujian Medical University, Dongfang Hospital of Xiamen University, 900th Hospital of the Joint Logistics Support Force, Fuzhou, P.R. China.
Chu J; Department of Respiratory and Critical Care Medicine, Fuzhou General Hospital of Fujian Medical University, Dongfang Hospital of Xiamen University, 900th Hospital of the Joint Logistics Support Force, Fuzhou, P.R. China.
Zhou X; Department of Respiratory and Critical Care Medicine, Fuzhou General Hospital of Fujian Medical University, Dongfang Hospital of Xiamen University, 900th Hospital of the Joint Logistics Support Force, Fuzhou, P.R. China.
Liu Y; Department of Respiratory and Critical Care Medicine, Fuzhou General Hospital of Fujian Medical University, Dongfang Hospital of Xiamen University, 900th Hospital of the Joint Logistics Support Force, Fuzhou, P.R. China.
Lai G; Department of Respiratory and Critical Care Medicine, Fuzhou General Hospital of Fujian Medical University, Dongfang Hospital of Xiamen University, 900th Hospital of the Joint Logistics Support Force, Fuzhou, P.R. China.

J Cell Biochem ; 120(10): 17602-17615, 2019 10.

Article en En | MEDLINE | ID: mdl-31237014

Asunto(s)

Fumar Cigarrillos/efectos adversos; Proteínas de la Membrana/genética; Mitocondrias/genética; Proteínas Mitocondriales/genética; Enfermedad Pulmonar Obstructiva Crónica/genética; Animales; Apoptosis/efectos de los fármacos; Autofagia/efectos de los fármacos; Autofagia/genética; Bronquios/efectos de los fármacos; Bronquios/metabolismo; Bronquios/patología; Fumar Cigarrillos/genética; Regulación de la Expresión Génica/efectos de los fármacos; Humanos; Pulmón/efectos de los fármacos; Pulmón/metabolismo; Pulmón/fisiología; Proteínas de la Membrana/antagonistas & inhibidores; Ratones; Mitocondrias/efectos de los fármacos; Proteínas Mitocondriales/antagonistas & inhibidores; Enfermedad Pulmonar Obstructiva Crónica/inducido químicamente; Enfermedad Pulmonar Obstructiva Crónica/patología; Enfermedad Pulmonar Obstructiva Crónica/terapia; Mucosa Respiratoria/efectos de los fármacos; Mucosa Respiratoria/metabolismo; Mucosa Respiratoria/patología; Nicotiana/química

Palabras clave

DRP1; FUNDC1; apoptosis; chronic obstructive pulmonary disease; cigarette smoke extract; mitochondrial autophagy

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad Pulmonar Obstructiva Crónica / Proteínas Mitocondriales / Fumar Cigarrillos / Proteínas de la Membrana / Mitocondrias Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Cell Biochem Año: 2019 Tipo del documento: Article

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