Palladium-Catalyzed ortho-C-H Methylation of Benzoic Acids.
J Org Chem
; 84(15): 9786-9791, 2019 Aug 02.
Article
en En
| MEDLINE
| ID: mdl-31248256
ABSTRACT
A palladium-catalyzed methylation of C-H bonds of benzoic acids with di-tert-butyl peroxide as the methylating reagent under an external oxidant and ligand-free conditions has been achieved. The reaction is found to be directed by a weakly coordinating carboxyl group, offering a facile route for the synthesis of highly functionalized ortho-methyl benzoic acids.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Año:
2019
Tipo del documento:
Article
País de afiliación:
China